4. Comprehensive Medical Evaluation 23 Flashcards
What is the current understanding regarding booster vaccines for people with diabetes?
It is currently unclear how often people with diabetes will require booster vaccines.
According to the article, what effect did remote consultations during the pandemic have on emotional distress related to mental health and diabetes?
Remote consultations during the pandemic reduced the prevalence of mental health- and diabetes-related emotional distress.
What are some longer-term psychological impacts of SARS-CoV-2 infection in people with diabetes?
fatigue and an increased risk of suicide.
What should health care professionals monitor people with diabetes for during the COVID-19 pandemic?
Health care professionals should carefully monitor people with diabetes for diabetic ketoacidosis.
Does Covid 19 increase risk for T1DM?
COVID-19 is associated with a significantly increased risk of new-onset type 1 diabetes.
Which type of diabetes has been associated with a higher risk of COVID-19 mortality?
Type 1 diabetes
What is the indicator of MORTALITY, in people with diabetes during COVID-19 admission?
Higher blood glucose levels both prior to and during COVID-19 admission.
What is the relationship between BMI and COVID-19 mortality in diabetes?
The relationship between BMI and COVID-19 mortality in both type 1 and type 2 diabetes is U-shaped.
What is the importance of regular follow-up for people with new-onset diabetes? after covid19
Regular follow-up for people with new-onset diabetes is important to determine if diabetes is transient.
What should health care professionals do during the COVID-19 pandemic in relation to people with diabetes?
Health care professionals need to carefully monitor people with diabetes for diabetic ketoacidosis during the COVID-19 pandemic.
What should healthcare professionals do to help people with diabetes in relation to glycemic control and COVID-19?
Healthcare professionals should help people with diabetes aim to achieve individualized targeted glycemic control to reduce the risk of macrovascular and microvascular complications as well as reduce the risk of COVID-19 and its complications.
Is statin therapy recommended for patients with decompensated cirrhosis?
No, statin therapy is not recommended in decompensated cirrhosis.
According to some studies, what impact may the use of certain medications have on people with chronic liver disease?
Their use may reduce episodes of hepatic decompensation and/or overall mortality.
What is the potential benefit of using certain medications in people with chronic liver disease?
Reduced episodes of hepatic decompensation and/or overall mortality.
Should statin therapy be initiated or continued for cardiovascular risk reduction in adults with type 2 diabetes and NASH?
Yes, statin therapy should be initiated or continued for cardiovascular risk reduction as clinically indicated.
Is the use of statin therapy considered safe in adults with type 2 diabetes and NASH?
Yes, the use of statin therapy appears to be safe in adults with type 2 diabetes and NASH.
Can metabolic surgery considered with compensated cirrhosis?
With CAUTION ONLY.
Who should metabolic surgery not be recommended for?
with decompensated cirrhosis who have a much higher risk of postoperative development of liver-related complications.
What are some complications associated with decompensated cirrhosis?
Some complications associated with decompensated cirrhosis include variceal hemorrhage, ascites, hepatic encephalopathy, or jaundice.
What percentage of improvement of NASH after metabolic surgery?
-50–75%
Seatosis higher
What is the improvement rate for fibrosis after metabolic surgery?
30-40%
WHAT IS THE PREFERRED T2DM MED and decompensated cirrhosis?
Insulin
Why is insulin the preferred glucose-lowering agent for the treatment of hyperglycemia in adults with type 2 diabetes and decompensated cirrhosis?
lack of evidence about the safety and efficacy of oral agents and noninsulin injectables.
Is metformin improve steatohepatitis in paired-biopsy studies?
No
Which medications have no RCTs with liver histological end points to prevent nash?
Sulfonylureas, glitinides, dipeptidyl peptidase 4 inhibitors, acarbose
Do Tirzepatide, sodium-glucose cotransporter inhibitors, and insulin reduce hepatic steatosis?
Yes for seatosis
But not for seatohepatitis!
Did GLP1 RA significantly affect the stage of liver fibrosis?
Only at higher doses….
The progression of liver fibrosis with the GLP-1 RA at the highest dose was 4.9% compared to 18.8% on placebo over 72 weeks.
What was the resolution of steatohepatitis in the group treated with semaglutide?
Yes
59% of the group treated with semaglutide experienced resolution of steatohepatitis.
compared with 17% in the placebo group
What is the main benefit of GLP-1 RAs in individuals with NASH?
- Weight Loss: GLP-1 RAs are effective in inducing weight loss.
- Improve LFT
- reduce steatosis
What did the small RCT find about liraglutide in individuals with NASH?
1-improving NASH
2-delay fibrosis
What are some potential side effects of Pioglitazone?
1- WT GAIN> dose dependant
2-HF
3- bladder cancer
4-fracture
In pt with NASH , is vitamin E effective?
DM pt > not effective
Other pt > effective
Did Vitamin E enhance the efficacy of pioglitazone when used in combination in people with type 2 diabetes?
No, it did not enhance pioglitazone’s efficacy.
What is the effect of pioglitazone treatment on NASH?
Pioglitazone treatment results in resolution of NASH.
How pioglitazone effect in resolution of NASH?
improve glucose and lipid metabolism and reverse steatohepatitis.
in people with prediabetes, type 2 diabetes, or even without diabetes.
What is the number one cause of death in people with type 2 diabetes and NAFLD?
Cardiovascular disease.
What are two health conditions associated with type 2 diabetes and NAFLD?
Cardiovascular disease and NAFLD.
Which medications have been shown to be effective in treating steatohepatitis?
Pioglitazone and some glucagon-like peptide 1 receptor agonists (GLP-1 RAs) have been shown to be effective in treating steatohepatitis.
What is the potential impact of pioglitazone and GLP-1 RAs on fibrosis progression?
Pioglitazone and GLP-1 RAs may slow fibrosis progression.
What dietary recommendations are effective for improving liver and cardiometabolic health in people with diabetes and obesity?
Dietary recommendations should include a reduction of macronutrient content, limiting saturated fat, starch, and added sugar, with adoption of healthier eating patterns such as the Mediterranean diet.
Which type of diet has the best evidence for improving liver and cardiometabolic health? In NAFLD PT ?
The Mediterranean diet
What types of exercise have been shown to improve Non-Alcoholic Fatty Liver Disease (NAFLD)?
Both aerobic and resistance training have been shown to improve NAFLD.
What is the recommended minimum weight loss goal for improving liver histology in people with overweight or obesity and NAFLD?
A minimum weight loss goal of 5%, preferably ≥10%, is needed to improve liver histology.
What effect does obesity have in the setting of type 2 diabetes and NAFLD?
Obesity worsens insulin resistance and steatohepatitis, promoting the development of cirrhosis.
What are the possible causes of steatohepatitis and cirrhosis in lean people with diabetes?
1-genetic predisposition
2-insulin resistance
3-environmental factors.
In what type of patients is metabolic surgery recommended with caution?
Metabolic surgery should be used with caution in adults with type 2 diabetes with compensated cirrhosis from nonalcoholic fatty liver disease.
Is metabolic surgery recommended in patients with decompensated cirrhosis?
No, metabolic surgery is not recommended in patients with decompensated cirrhosis.
What is one potential treatment option for adults with type 2 diabetes and nonalcoholic steatohepatitis?
Metabolic surgery can be considered as an option to treat nonalcoholic steatohepatitis in adults with type 2 diabetes and nonalcoholic steatohepatitis and improve cardiovascular outcome.
What is the recommendation for managing cardiovascular risk factors in adults with type 2 diabetes and nonalcoholic fatty liver disease?
Comprehensive management of cardiovascular risk factors is recommended.
Is statin therapy safe for adults with type 2 diabetes and compensated cirrhosis from nonalcoholic fatty liver disease?
Yes, statin therapy is safe for adults with type 2 diabetes and compensated cirrhosis from nonalcoholic fatty liver disease.
How should statin therapy be used in people with decompensated cirrhosis?
In caution only
What is the preferred agent for the treatment of hyperglycemia in adults with type 2 diabetes with decompensated cirrhosis?
Insulin therapy
According to the provided information, which glucose-lowering therapies may be continued as clinically indicated in adults with type 2 diabetes and nonalcoholic steatohepatitis?
V pioglitazone
V SGLT2i
V insulin
V DPP4i
! SU > hypos
! METFORMIN > lactic acidosis
Is there evidence of benefit in nonalcoholic steatohepatitis for glucose-lowering therapies other than pioglitazone or glucagon-like peptide 1 receptor agonists?
No
What is the preferred treatment for hyperglycemia in adults with type 2 diabetes and nonalcoholic steatohepatitis?
Pioglitazone or glucagon-like peptide 1 receptor agonists.
What is the adjunctive therapy recommended for weight loss in adults with type 2 diabetes and nonalcoholic fatty liver disease?
GLP1RA
What should be recommended to adults with type 2 diabetes or prediabetes AND NAFLD?
LMS for Wt reduction:
-DIET
-Exercises: aerobic and anaerobic.
What is the best-validated imaging technique for fibrosis risk stratification in NAFLD?
The best-validated imaging technique for fibrosis risk stratification in NAFLD is transient elastography (LSM).