4/7 ID: A Way of Thinking + Ch 5

Question 1

Definition of prophylactic use of antibiotics?

Answer 1

Patient who is at risk is given antibiotic to prevent infection

Ex: TMP/SMX to prevent recurrent UTIs

Question 2

Definition of empiric use of antibiotics?

Answer 2

Patient with evidence of infection is given antibiotic to cover the likely orgs before specific organizms have been isolated

Ex: community-acquired pneumonia: treat empirically with ceftriaxone

Question 3

definition of therapeutic use of antibiotics?

Answer 3

Specific antibiotic to cover a specific organism that has been isolated and identified

ex: bloodstream infection due to E Coli –> cefazolin

Question 4

what does Parenteral mean?

Answer 4

delivered IM or IV rather than PO

Question 5

What is the MIC method for sensitivity testing?

Answer 5

MIC = minimum inhibitory concentration

min conc of antibiotic required to inihbit growth of an organism in vitro within 24h

Question 6

what is MBC?

Answer 6

MBC = minimum bactericidal concentration

min conc of antibiotic required to kill 99.9% of an organism in vitro within 48h