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PMCOL 303 > 4 > Flashcards

4 Flashcards

1
Q

how can cancers protect from anti-cancer drugs

A

upregulate anti-oxidant systems

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2
Q

which amino acids can be quenching systems

A

glutathiuone, tocopherol, ascorbate

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3
Q

what is the pepetide formula for glutathione

A

ECG

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4
Q

what is avaulabvlr for redox reactions and conjugation with xenobiottics

A

cysteine sulfhyrdyrl

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5
Q

where are cojugates transported to in the liver

A

bile, excreted as mercaptic acid

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6
Q

what are 4 important ions

A

na ca cl h

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7
Q

what are the two important transpotter families

A

SLC, solute carrier ABC ATP binding cassette

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8
Q

what do ABCs include

A

MDR BSEP MRP BCRP

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9
Q

what do SLC include

A

OATP OAT OCT PEPT

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10
Q

what do SLC include

A

OATP OAT OCT PEPT

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11
Q

what does SLC6 transport

A

neurotransmitters

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12
Q

what does SLC22 transportt

A

organic cations or anions

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13
Q

what is the strcuture of MDRs

A

N +2x (6 domains +ABC) + C

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14
Q

what shape do MDRs formc

A

pore that translocates ligands

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15
Q

describe the MDR transport cycle

A
  1. open face toward cytosol, ligand binds
  2. ligand binding causes ABCs to dimerize while pore opens to outside
  3. ATP hydrolysis
  4. conformational change reveals inward facing pocket
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16
Q

what is syructure of SLC family proteins

A

5+5 MOTIF with addtional C or 2 additional N

17
Q

what are SLC transporters powered by

A

Na or Cl

18
Q

what is the transport cycle for SLC

A

Na and Cl bind in occluded pocket, outward gate open

substrate binds pocket and outward gate closes

transmembrane helices shift removing occlusion, inward gate open releasing Na, Cl, and substrate

outward gate ipens creating open channel, shift

19
Q

what controls the genes for proteins for angti-oxidant systems

A

ARE

20
Q

how does ARE work

A

Nrf2 translocate to nucleus and promote transciprtion by binding AREs

21
Q

what is the half life of Nrf2

A

20 minutes

22
Q

how does Nrf2 get degraded

A

ubitiquination

23
Q

what does Keap 1 dp

A

localises Cul3 to Nrf2 and sense oxidartive tress

24
Q

what is Cul3

A

ubitiquin ligase that tags Nrf2 for degradation

25
Q

what does ECM contain

A

inactive TGFbeta

PMCOL 303 (4 decks)

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