1 Flashcards
what is a xenobiotic
any foreign compound not normally found in an organism
what is poison
any damage inducing compound
what is a toxin
any damage inducing compound that is naturally occuring
what is a toxicant
any manmade damage inducing compound
what is venom
any naturally occurring damage inducing compound delivered by an apparatus
what are the two key factors in toxic response studies
safety and efficacy
how many animals shows statistical signficance
1000
what is acute
24 hours
what is subacute
<1 month
what is subchronic
1-3 months
what is chronic
> 3 months
what is the usual dose used from chronic testing
MTD
what is MTD
no weight gain over 90 days
what can you use for pharmacokinetic data
AUC
what is the daily dose for a therapeutic human dose
25xAUC
what are the two types of responses
quantal and graded
how are quantal responses usually expressed
as probability units (probits)
which response type shoes dose the responses
graded
what distribution is typical of quantal data
gaussian
why is gaussian distrubtion typcial of quantal data
genetics and environment
which percentiles occur within the linear segment
16-84
what are NEDs
percentage of responses relative to the mean
how to caclulate probit
NED +5
how to calculate TI
TD50/ED50
