1 Flashcards
1
Q
what is a xenobiotic
A
any foreign compound not normally found in an organism
2
Q
what is poison
A
any damage inducing compound
3
Q
what is a toxin
A
any damage inducing compound that is naturally occuring
4
Q
what is a toxicant
A
any manmade damage inducing compound
5
Q
what is venom
A
any naturally occurring damage inducing compound delivered by an apparatus
6
Q
what are the two key factors in toxic response studies
A
safety and efficacy
7
Q
how many animals shows statistical signficance
A
1000
8
Q
what is acute
A
24 hours
9
Q
what is subacute
A
<1 month
10
Q
what is subchronic
A
1-3 months
11
Q
what is chronic
A
> 3 months
12
Q
what is the usual dose used from chronic testing
A
MTD
13
Q
what is MTD
A
no weight gain over 90 days
14
Q
what can you use for pharmacokinetic data
A
AUC
15
Q
what is the daily dose for a therapeutic human dose
A
25xAUC
