3 Flashcards
toxicokinetics or toxicodynamics split into toward or away
toxicokinetics
what do toxicodynamics describe
toxicity
what are the four factors involved in toxcitiy
toxicant target, cell signalling, cell sttress, death pathways
what are the tthree main targets
lipid protein nucleic acid
what must targets be
reactive accesible, altered function
what are some sugnalling currencies
association/disossiaction, conformation, localization, post trasnlational modifcations
tissue repair causes toxicity by
apoptosis
the effectts of toxciity on ptoein, lipid and NA occur during ___ (signalling or repair)
repair
what can cause short term toxciity
Na channrl toxins
what 2 things can cause long term toxicity
benzene-DNA adducts, mutations
what are the three main major causes of poison induced cell death
intracellular Ca, ATP depletion, ROS/RNS
what are the 4 mechanisms of increased Ca
`iopening ligand gated channels, ER, mitochonidra, reduced effluc
what happens as a result of elevated Ca (7)
cytoskeleton disintegrates
membrane anchoring removed
blebbing
membrane rupture
Ca-depedent enzymes
phospholipase modify membrane lipids
endonucleases fragment DNA
what does ATP and ADP hydroylsis lead to
phosphoric acid accumulation
what occurs as a result of phosphoric acid accumulation
lower pH of cytosol –> calcium phosphate precipitates, lowering Ca, inhibits Ca enzymes (phospholipase) –> ATP pumps shut down —> cellular water and ionic balance tilt
