2 Flashcards
what family transports organic cations and anions
SLC22
is uptake active or passive
passive
what do poisons target
transmembrane receptors, cytosolic proteins, nucleic acids
which organelle plays a deciding role in cell death
mitochondira
what is uneven cleavage
heterolytic
what is superoxide biotransformation into RNS via
peroxynitrate + CO2 –> nitrosoperoxy carbonate —> NO2 and carbonate anion radicals
how are ROS generated `
h2o2 OH electrophile and nucleophile
how is H2O2 generated
superoxide dismutase ub mitochodnria combines H+ with superoxide
what is the poison action at lipids
peroxidation
what is the poison action at porteins
crosslinking, fragmentation, carbonyl aldehydes and ketones
what is the poison action at nucleic acids
oxidation, crosslinking, strand breaks
what does lipid peroxidation generate
alpha,beta-unsatturated aldehydes
which side chains are susceptible to attack the positive charge on the alpha beta unsaturated aldehyde
C H K
where is electron density withdrawn from
C3
what is the % distribution of michael adducts to schiff bases
80% to 20%
what is the michael adduct generated by
nucleophilic attack of C3
what is thr schiff adduct generated by
nucleophilic attack of aldehyde carbon
which adduct forms pyrrole ring
schiff
which adduct forms lactol like ring
michael
which amino acid is modified to form a pyrolle ring
K
