2

Question 1

what family transports organic cations and anions

Answer 1

SLC22

Question 2

is uptake active or passive

Answer 2

passive

Question 3

what do poisons target

Answer 3

transmembrane receptors, cytosolic proteins, nucleic acids

Question 4

which organelle plays a deciding role in cell death

Answer 4

mitochondira

Question 5

what is uneven cleavage

Answer 5

heterolytic

Question 6

what is superoxide biotransformation into RNS via

Answer 6

peroxynitrate + CO2 –> nitrosoperoxy carbonate —> NO2 and carbonate anion radicals

Question 7

how are ROS generated `

Answer 7

h2o2 OH electrophile and nucleophile

Question 8

how is H2O2 generated

Answer 8

superoxide dismutase ub mitochodnria combines H+ with superoxide

Question 9

what is the poison action at lipids

Answer 9

peroxidation

Question 10

what is the poison action at porteins

Answer 10

crosslinking, fragmentation, carbonyl aldehydes and ketones

Question 11

what is the poison action at nucleic acids

Answer 11

oxidation, crosslinking, strand breaks

Question 12

what does lipid peroxidation generate

Answer 12

alpha,beta-unsatturated aldehydes

Question 13

which side chains are susceptible to attack the positive charge on the alpha beta unsaturated aldehyde

Answer 13

C H K

Question 14

where is electron density withdrawn from

Answer 14

C3

Question 15

what is the % distribution of michael adducts to schiff bases

Answer 15

80% to 20%

Question 16

what is the michael adduct generated by

Answer 16

nucleophilic attack of C3

Question 17

what is thr schiff adduct generated by

Answer 17

nucleophilic attack of aldehyde carbon

Question 18

which adduct forms pyrrole ring

Answer 18

schiff

Question 19

which adduct forms lactol like ring

Answer 19

michael

Question 20

which amino acid is modified to form a pyrolle ring

Answer 20

K