4

Question 1

Benzodiazepines

Answer 1

Bind to a subunit of GABA-A receptors and facilitate GABA transmission (increase likehood of Cl- channel opening). Many many forms but 3 mains groups :

Question 2

Barbiturates

Answer 2

Bind to physically different site on the receptor than benzodiazepines and facilitate GABA transmission (increase likehood of Cl- channel opening and duration of opening). Ex : pentobarbital

Question 3

test anxiety ?

Answer 3

induce social fear, avoidance conflict test, latency to go to food pellet

Question 4

Antidepressants ?

Answer 4

trycyclic, SSRI : serotonine selective reuptake inhi. Citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline
NRI : reboxetine
SNRI (mixed 5-HT / NE) : Serotonine + norad transporters. venlafaxine, duloxetine, milnacipran
MAOI : tranylcypromine, phenelzine
Others : bupropion, mirtazepine, trazodone, ketamine (NMDA antagonist)
ECT (electro convulsivo therapy): 6-8 generalized seizures over 2-3 weeks
Transcranial magnetic stimulation (TMS)
Transcranial direct current stimulation (tDCS) : not invasive, just on the brain

Question 5

tricyclic

Answer 5

amitriptyline, imipramine, clomipramine (> 5-HT)
nortriptyline, desipramine (> NE)
Serotonine + norad transporters

Question 6

type of validity to look for ?

Answer 6

Faith validity : same symptomes
Construct/Pharmacological validity : drug act on the same way in model and human
Aetiologic/Predictive validity : same biological marker

Question 7

Learned Helplessness model

Answer 7

Alteration du REM sleep, weight loss, decreased sexual behavior, Increase levels of CRF and corticosterone. Sensitive to antidepressants and ECT.
in species