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Question 1

what is the drug action ?

Answer 1

molecular changes produced by a drug when t bind its target

Question 2

what are the two aspects of drug action ?

Answer 2

Potency and efficacy

Question 3

site the six mechanism of drug action

Answer 3

receptor, enzyme, ion chnnel, transport system trans factor, nucleid acid

Question 4

what are receptors

Answer 4

proteins prticipate in intracellular comm via chemical signal

Question 5

can receptors be found in cytoplasm ?

Answer 5

yep

Question 6

which properties of receptors ?

Answer 6

saturability , reversibilityy (weak intermolar forces, vnderwalls)
stereoselectivity (recpgnize only one isomers)
agonist specificity related drug brind well and dissimilar compounds should bind poorly

Question 7

tw0 phases of receptor propeties ?

Answer 7

Recognition, tranduction (functionnal response).

Question 8

subpart of receptor

Answer 8

ligand binding domain, effector domain ssecond messenger

Question 9

how is called receptor PLUS CELLULAR TARGET PLUS INTERMEDIARY MOLECULE ?

Answer 9

RECEPTOR EFFECTRS SYSTEM OR SIGNAL TRANSDUCTION PATHWAY

Question 10

What are cell surfae receptor ?

Answer 10

ion gated or metabotropic (g coupled or tyrosine kinase linked receptor)

Question 11

what are nuclar receptor ?

Answer 11

hormone

Question 12

what trigers ions channel ?

Answer 12

change in membrane potential or ionic concentration

Question 13

what triggers protein phosphorilation ?

Answer 13

cellular effect

Question 14

What triggrs g protein ?

Answer 14

2nd messenger CAMP and cellular effect

Question 15

what type are nAchR, NMDA r, GABAA ?

Answer 15

ionotropoc

Question 16

what are ownstream effect of tirosine kinase linked receptor ?

Answer 16

for receptor dimer and activate tyrosine linase that results in phosporilation of downstream target.

Question 17

WHat receptors are NGF, PDGF, insulin ?

Answer 17

tyrsine linked receptrs

Question 18

what is transcripton facotr ?

Answer 18

lingand binding domainDNA binding domain that mediates binding to specific sites on the genome for activate or inhibit transcritpion of the nearby gene.

Question 19

hw to measure basic radioligand binding/affinity ?

Answer 19

{L} plus {R} egal LR plus LFREE(ligand qui accroche pas au recepteur)

Question 20

how is measured LR

Answer 20

radioligand binding

Question 21

how to discriminate bewteen specific and nonspecific binding ?

Answer 21

using radilabelled ligands: radiolabelled ligand has nochance to compete with the unlabelled ligand added in excess : bound activity = non specific + specific binding

or bound radioactivity 1st set of tubes - br 2d set of tubes = bound activity due to specific binding

Question 22

whats pccupancy theory ?

Answer 22

effect of a drug is proportionnal to nbr of receptor that is occupied by th edrug and has its basis in the law of mass action. Max response occurs whrn all receptors anre bound.

Question 23

diff type of agonist ?

Answer 23

full agonist, partial, inverse agonist, super agonist, endogenous agonist

Question 24

what is intrinsic activity ?

Answer 24

drug ability to bind a receptor and elicit a functional responde ?

Question 25

types of antagonism ?

Answer 25

competitive vs non competitive

Question 26

competitive abtagonism ?

Answer 26

bibds t same receptor as aonist

Question 27

no competitiva antagonism ?

Answer 27

binds to distinc site than agonist

Question 28

therapeutic index ?

Answer 28

therapeutic vs toxic effect