3.8 Sexually Transmitted Infections Flashcards
Trichomonas vaginalis description and symptoms
Protozoan
often asymptomatic
mild irritation to severe inflammation
How do you treat trichomonas vaginalis?
metronidazole or trinidazole
Who is trichomonas vaginalis more common in?
Indigenous
how does chlaymidia trachomatis gain entry and replicate?
Exogenous entry, intracellular replication (requires hot products for growth, can only reproduce when inside the eukaryotic cell host, cannot culture on inert media)
What is the structure of chlaymidia trachomatis?
outer membrane stabilised by major outer membrane proteins and cysteine rich proteins with no peptidoglycan layer
What are the biphasic sturctures of chlaymidia trachomatis ?
Elementary bodies: extracellular metabolically inert that do not divide
Reticulate bodies: intracellular metabolically active form which replicates within the endosome
Neisseria Gonorrhoeae
Gram negative diplococci - facultative intracellular bacteria
Mechanism of entry of Neisseria Gonorrhoeae
Fimbriae of pili attach to non ciliated epithelial cells in the cervix and urethra
Pili undergo antigenic variation
Who is Chlamydia most prevalent in?
Females 15-24 and indigenous and remote areas
Who is gonococcal most common in?
males - especially men who have sex with men and indigenous
Describe chlamydia trachomatis
obligate intracellular bacterium with an atypical cell wall
What are the manifestations of chlamydia?
Reactive arthritis
Reiters syndrome (urethritis, conjunctivitis and arthritis)
Perihepatitis
What are the manifestations of Gonorrhoea
Disseminated infection (endocarditis) Septic arthritis Reactive arthritis conjunctivitis perihepatitis
How do you diagnose chlamydia
cannot grow on inert media so now do PCR
How do you diagnose Gonorrhoea?
Can grow on media that inhibits other bacteria
PCR
