3.4 venous thrombosis Flashcards
1
Q
where does factor V leisin work?
A
clotting factors V/Xa
2
Q
venous thrombosis
A
consider hereditary thrombophilia screening
3
Q
what is a stronger risk factor
-antiphospholipid antibody syndrome
or
-hereditary thrombophilia?
A
antiphospholipid syndrome
4
Q
antiphospholipid pathogenesis
A
antibodies lead to conformational change in b2-glycoprotein 1
activates primary and secondary haemostasis and vessel wall abnormalities
5
Q
what are antiphospholipid antibodies specific for?
A
ANIONIC (negative) phospholipids
prolong photpholipid dependent coagulation tests in vitro (test tube = lupus anticoagulant)
6
Q
conditions associated with antiphospholipid antibodies
A
autoimmune disorder lymphoproliferative disorder viral infections drugs primary
