3.03 bleeding disorders

Question 1

purpura 
joint pain 
abdo pain 
bruising/bleeding 
immune complex deposition of IgA 
systemic vasculitis 
child

Answer 1

henoch-scholein purpura

Question 2

consumptive coagulopathy in seriously ill patient
clotting factors and platelets consumed

-sepsis
-amniotic fluid embolism
-cancer, esp carcniomas
= multi organ failure, bleeding

Answer 2

Disseminated intravascular coagulation

Question 3

decreased platelet count
bleeding 
normal for every other blood parameter
-mild
-self limiting (esp in children)

Answer 3

immune thrombocytopaenia purpura

Question 4

inheritance pattern of von willebrand factor deficiency

Answer 4

autosomal dominant

incomplete penetrance- variable severity

Question 5

clotting factors carboxylated by vitamin K?

Answer 5

II, VII, IX, X
protein C
protein S

Question 6

inheritance pattern of haemophilia a and b

Answer 6

x-linked
haemophilia a- factor VIII deficiency
haemophilia b- factor IX deficiency