1.01 Intro to Haem Flashcards
Where does the embryo/fetus make blood?
yolk sac
liver
in 3-rd to 7th month in utero- spleen
where does the newborn make blood?
bone marrow
lesser extent liver and spleen when needed
Where do adults make blood?
bone marrow of skull ribs sternum pelvis proximal ends of femur
How many platelets, RBC, and neutrophis are we making per minute?
150 million platelets
100 million RBC
60 million neutrophils
per minute
T/F Most stem cells are quiescent?
True
What are the precursor cells of a neutrophil?
myeloblast promyelocyte myelocyte metamyelocyte band forms neutrophils
What are the precursor cells of an RBC/erythrocyte?
pronormoblast
basophilic/early normoblast
polychromatophilic/intermediate normoblast
orthochromatic/late normoblast
reticolocyte
mature red cell/erythrocyte
What is the structure and function of neutrophils?
segmented neucleus; neutral staining granules
short life in circulation, phagocytosis and granule-mediated killing of cells
increased by stress- infection, trauma, infarction
What is the structure/function of eosinophils?
bi-lobed right orange/red granules
fight parasites
hypersensitivty- allergic reactions
elevated in allergic conditions- asthma, atopic rhinitis
What is the structure of basophils?
large deep purple granules obscuring nucleus
What do basophil granules contain?
histamine
What is the general function of basophils
circulating tissue mast cell role unclear mediates hypersensitivity reactions Fc receptors bind IgE granules containing histamine
What is the appearance of monocyte?
large single nucleus
faintly staining granules
vacuolated
What is the function of monocytes?
circulate x 1 week - enter tissues to become macrophage
phagocytose invaders, present antigen to lymphocytes
attract other cells
longer lived than neutrophils
What is the appearnce of lymphocytes?
small with condensed nucleus and rim of cytoplasm
if activated- large +++ cytoplasm, open nucleus
