33 NSAIDS

Question 1

Mechanism of action for NSAIDS

Answer 1

Inhibit COX 1 and COX 2 enzymes (cyclo-oxygenase) which are related to the synthesis of prostaglandins and thromboxane. Does so through reversible competition with arachidonic acid

Question 2

Describe normal prostaglandin synthesis

Answer 2

Arachidonic acid binds to cyclooxyrgenase enzymes and prostaglandin and thromboxane synthesis occurs.

Question 3

Result of COX 1 inhibition

Answer 3

Most notable GI eroisions

Question 4

Result of COX 2 inhibition

Answer 4

antipyresis, analgesia, anti-inflammation

Question 5

Name three traditional NSAIDS

Answer 5

Aspirin
Diclofenac
Ibuprofen
Indomethacin (preterm labour prevention)

Question 6

Side effects of NSAIDS

Answer 6

Bleeding (thromboxane inhibition)
Gastric ulcers/ bleeding (prostaglandins have role in protective gut mucosa)
Na+, H2O, K+ retention (due to prostaglandin roles in kidneys). Dont use in renal patients.
Asthma- may precipitate bronchioconstriction

Question 7

Prostaglandins and labour

Answer 7

Role in establishing and maintaining contractions. Also maintain patency of DA.
Indomethacin can help prevent preterm labour and is used to close a patent DA

Question 8

Drug interactions

Answer 8

High protein binding. Can displace other drugs that bind to protein increasing free concentrations.