3.2 catabolic core of mechanism Flashcards
what are the 4 processes of aerobic respiration
glycolysis, link reaction, Krebs cycle, oxidative phosphorylation
what are the 3 enzymes involved in glycolysis
hexose kinase
PFK
pyruvate kinase
what does hexose kinase do
Converting Blood glucose into glucose 6 phosphate using energy
what does PFK do
Converting fructose 6 phosphate into fructose 1,6 bisphosphate
what does pyruvate kinase do
converts 2 PEP into 2 pyruvate
what inhibits hexose kinase
glucose 6 phosphate
what inhibits and activates PFK
inhibits: ATP, citrate, H+
activates: AMP
what inhibits and activates pyruvate kinase
ATP inhibits
F16BP activates
what are the fate of pyruvate and NADH after glycolysis
- Pyruvate is converted into acetyl CoA and is used in the CAC (citric acid cycle) (AKA Krebs cycle)
- NADH donates its electrons to the electron transport chain to generate more ATP
what happens in anaerobic conditions
In anaerobic conditions, the electron transport chain cannot accept more electrons since there are no oxygen to accept the electrons
○ Hence pyruvate is converted into lactate (NADH -> NAD+)
This regenerates NAD+ can accept more electrons from glycolysis, allowing the pathway to continue
what happens to anaerobic microorganisms
Similarly, specific microorganisms anaerobically covert pyruvate into ethanol, regenerating NAD+
what enzyme is involved in link reaction
pyruvate dehydrogenase
what does pyruvate dehydrogenase do
converts pyruvate into acetyl CoA
what inhibits and activates pyruvate dehydrogenase
inhibits: acetyl CoA, ATP, NADH
activates: pyruvate, insulin
what happens in Krebs cycle
Acetyl CoA (2C) reacts with oxaloacetate (4C) to make citrate (6C)
