3.1 CYTOKINES/ GROWTH FACTORS Flashcards
EPO PCS
❖ Kidney (peritubular interstitial cell)
EPO PTC
❖ Bone marrow erythroid progenitors (BFU-E and CFU-E)
EPO BA
❖ Simulates proliferation of erythroid progenitors and prevents apoptosis of CFU-E
G-CSF PTC
❖ Neutrophil precursors
❖ Fibroblasts
❖ Leukemic myeloblasts
G-CSF BA
❖ Stimulates granulocyte colonies ❖ Differentiation of progenitors toward neutrophil lineage
❖ Stimulation of neutrophil maturation
GM-CSF PTC
❖ Bone marrow progenitor cells
❖ Dendritic cells
❖ Macrophages
❖ NKT cells
GM-CSF BA
❖ Promotes antigen presentation
❖ T cell homeostasis
❖ Hematopoietic cell growth factor
IL-2 PTC
❖ T cells
❖ NK cells
❖ B cells
❖ Monocytes
IL-2 BA
❖ Cell growth/activation of CD4+ and CD8+ T cells
❖ Suppress Treg responses
❖ Mediator of immune tolerance
IL-3 PTC
❖ Hematopoietic stem cells and progenitors
Multi potential CSF
IL-3
IL-3 Works with?
SCF
IL3 WORKS WITH SCF FOR?
BASOPHIL DIFFERENTIATION
IL-3 BA
❖ Proliferation of hematopoietic progenitors
IL-3 difference with GM-CSF
IL-3 works at earlier level
