300 corticosteroids Flashcards
corticosteroids, anti-inflammatory(steroid)
dexamethasone
prednisone
methylprednisolone
The short term effects of corticosteroids are decreased vasodilation and permeability of capillaries, as well as decreased leukocyte migration to sites of inflammation.3 Corticosteroids binding to the glucocorticoid receptor mediates changes in gene expression that lead to multiple downstream effects over hours to days.3
Glucocorticoids inhibit neutrophil apoptosis and demargination; they inhibit phospholipase A2, which decreases the formation of arachidonic acid derivatives; they inhibit NF-Kappa B and other inflammatory transcription factors; they promote anti-inflammatory genes like interleukin-10.3
Lower doses of corticosteroids provide an anti-inflammatory effect, while higher doses are immunosuppressive
indications
- severe asthma
- anaphylaxis
- exacerbation COPD
- urticaria
- pneumonias(new COVID)
- croup
contraindications
- mindful of untreated infection
- none for sever emergencies( anaphylaxis)
s/s common
- htn
- n/v
- vertigo
- headache
- hyperglycemia
- edema(fluid retention)
- gi bleeds with prolonged use
- longer healing times for wounds
dexamethasone
Decadron
name
dex-a-meth-asone (dex a methhead in the zone)
DEC-A-DRON (transformer name for a dron-e)
dose
4-10mg SIVP
notes
s/s vertigo, gi bleed after prolonged use, abdo extension
slow onset
single dose prehospital
protect from heat
methylprednisolone
SOLU-MEDROL
NAME
meth-yl-predni-so-lone
SOLU-MEDROL
DOSE
125-250mgSIVP/IO
notes
s/s CHF, malaise, hiccups
prednisone
WINIPRED
NAME
predni-sone (zone but with an s)
WINIPRED (wini the pooh loves eating honey prednisone at age 40-60)
dose
40-60 mg po day
notes
s/s
caution with hepatic impairment
angioedema
cardiac arrest
contra
untreated fungal infections
Cushing’s syndrome
cant swallow
measles
precautions mix with many drugs
- aspirin
- heparin
- warfarin
- colchicine
- diltiazem
