30. Patho- and morphogenesis of different forms of glomerulonephritis (GNs). Exudative glomerulonephritis

Question 1

glomerulonephritis is which kind of nephritis?

Answer 1

non-suppurative nephritis

Question 2

glomerulonephritis is asending or descending ?

Answer 2

descending

Question 3

causes of glomerulonephritis

Answer 3

• bacterial
• viral systemic disease
• chemical
• immunological

Question 4

example of viral cause of glomerulonephritis

Answer 4

• newcastle disease
• swine fever
• infectious canine hepatitis
• porcine cytomegalovirus

Question 5

example of chemical cause of glomerulonephritis

Answer 5

• cyclosporine
• gold

Question 6

Immunological cause of glomerulonephritis

Answer 6

• Immuncomplex (80% type 3, vasculitis)
• nephrotoxic (20% type 2, cytotoxic)

Question 7

macroscopic features of glomerulonephritis

Answer 7

• enlarged
• moist
• pale
• petechiae in cortext

petechiae =. enlarged & hyperaemic glomeruli

Question 8

nephrotoxic glomerulonephritis

Answer 8

binding of spe Ab to cell Ag
- blood group antigens (transfusion)
- good pasture syndrome
- myasthenia gravis

type 2

Question 9

immune-complex glomerulonephritis

Answer 9

immune complex formation & deposition at filtration barrier

prolonged damage to glomeruli

Question 10

exudative glomerulonephritis

Answer 10

1st stage of inflammatory process
- seen in canin infectious hepatitis (adenovirus)
- septicaemic erysipelas & swine fever

hyaline & fibrin can be present in capillary loops

Question 11

Proliferative glomerulonephritis

Answer 11

glomerulonephritis with mesengial cell proliferation
- consequence of interstitial nephritis in aleutian mink disease

Question 12

Sclerosing glomerulonephritis

Answer 12

accumulation of mesangial cells + matrix

Question 13

Membranous glomerulonephritis

Answer 13

granular deposition IC
- formation of ‘spikes’ towards lumen
- basement membrane thicker & uneven