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Microbiology and Parasitology > 3-Virology > Flashcards

3-Virology Flashcards

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Biology 101 flashcards
2
Q

All viruses are haploid EXCEPT

A

Retroviruses

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3
Q

All DNA viruses have double-stranded DNA EXCEPT

A

Parvovirus

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4
Q

All RNA viruses have single-stranded RNA EXCEPT

A

Reoviruses

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5
Q

All double-stranded DNA viruses are icosahedral EXCEPT

A

Poxvirus

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6
Q

Father of vaccination

A

Edward Jenner

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7
Q

Creutzfeldt-Jakob disease (cognitive or cerebellar?)

A

Cognitive

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8
Q

Kuru (cognitive or cerebellar?)

A

Cerebellar

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9
Q

Erythema infectiosum

A

Parvovirus B19

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10
Q

Aplastic anemia in children with sickle cell

A

Parvovirus B19

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11
Q

MCC of viral conjunctivitis

A

Adenovirus

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12
Q

How many adenovirus serotypes?

A

41

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13
Q

Koilochtes

A

HPV

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14
Q

Gene involve in the suppression of tumor suppressor genes in HPV

A

E6, E7

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15
Q

Condylomata acuminata

A

HPV

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16
Q

Tzank smear

A

HSV

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17
Q

What do you see in Tzank smear?

A

Multinucleated giant cells

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18
Q

HSV on brain biopsy

A

Cowdry type A

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19
Q

Temporal lobe encephalitis

A

HSV-1

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20
Q

Thalamic encephalitis

A

Japanese B encephalitis

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21
Q

Centrifugal rash 2 weeks postrespiratory infection

A

VZV

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22
Q

Dewdrop on a rose appearance

A

VZV

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23
Q

Site of latency in VZV

A

Dorsal root ganglion

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24
Q

Reactivated VZV

A

Shingles

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25
Q

MCC of congenital abnormalities

A

CMV

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26
Q

Heterophil-negative mononucleosis

A

CMV, toxoplasmosis gondii

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27
Q

DOC of HSV

A

Acyclovir

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28
Q

Rare complication: splenic rupture

A

EBV

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29
Q

Kissing disease

A

EBV

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30
Q

Burkitt’s lymphoma in Africans

A

EBV

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31
Q

Hairy cell leukoplakia in HIV

A

EBV

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32
Q

Nasopharyngeal carcinoma in Chinese

A

EBV

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33
Q

Heterophil-positive mononucleosis

A

EBV

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34
Q

DOC of Hepatitis B

A

Lamivudine

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35
Q

Dane particles

A

Hepatitis B

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36
Q

Necrotic hepatocytes in Hepatitis B

A

Councilman Bodies

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37
Q

Necrotic hepatocytes in alcoholic hepatitis

A

Mallory bodies

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38
Q

Blueberry muffin appearance

A

Congenital rubella, CMV, disseminated neuroblastoma

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39
Q

Roseola infantum AKA

A

Exanthem sobitum

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40
Q

Marker of Hepatitis B infection

A

HBsAg

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41
Q

Marker of infectivity in Hepatitis B

A

HBeAg

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42
Q

Marker of active viral replication in Hepatitis B

A

HBeAg

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43
Q

Marker for seroconversion in Hepatitis B

A

Anti-HBsAg

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44
Q

The only marker during the “window” period in Hepatitis B

A

Anti-HBcAg

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45
Q

Replicates in the motor neuron in the anterior horn cells of the spinal cord

A

Poliovirus

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46
Q

MCC in viral myocarditis and pericarditis

A

Coxsackie type B

47
Q

Herpangina, hand-foot-and-mouth disease, hemorrhagic conjunctivitis

A

Coxsackie type A

48
Q

MCC of viral meningitis

A

Coxsackie virus

49
Q

High mortaility in pregnant women

A

Hepatitis E virus

50
Q

MCC of nonbacterial diarrhea in adults

A

Norwalk virus

51
Q

Norwalk virus AKA

A

Norovirus

52
Q

MCC of childhood diarrhea

A

Rotavirus

53
Q

Capable of undergoing antigenic shifts and drifts

A

Influenza virus

54
Q

Latest strain of influenza virus

A

H7N9

55
Q

Warthin-Finkeldy bodies

A

Measles

56
Q

Rubeola

A

Measles

57
Q

Koplik spots

A

Measles

58
Q

SSPE

A

Measles

59
Q

Damson’s disease

A

Measles

60
Q

Tender swelling of the parotid glands

A

Parotitis

61
Q

Causes parotitis

A

Mumps

62
Q

Complications of mumps

A

Orchitis, meningitis

63
Q

MCC of pneumonia and bronchiolitis in infants

A

RSV

64
Q

DOC of Actinomycosis

A

Penicillin

65
Q

DOC of Nocardia

A

Sulfa drugs

66
Q

Laryngotracheobronchitis

A

Parainfluenza virus

67
Q

Steeple sign

A

Laryngotracheobronchitis

68
Q

DOC for Laryngotracheobronchitis

A

Racemic epinephrine

69
Q

Negri bodies

A

Rabies virus

70
Q

Fatality in rabies when encephalitis develops is secondary to?

A

Early brainstem dysfunction

71
Q

SARS

A

Coronavirus

72
Q

Horseshoe bats

A

SARS; coronavirus

73
Q

Virus binds to ACE-2 receptor

A

Coronavirus

74
Q

CXR finding in SARS

A

“Ground-glass” appearance

75
Q

Vector for dengue fever

A

Aedes aegypti

76
Q

Gold standard test for DF

A

Dengue RTPCR test

77
Q

Breakbone fever

A

Dengue fever

78
Q

Herman’s rash

A

Dengue fever

79
Q

Most prevalent blood-borne pathogen

A

Hepatitis C virus

80
Q

Main cause of essential mixed cryoglobulinemia

A

Hepatitis C virus

81
Q

“3 day” measles

A

German measles

82
Q

German measles

A

Rubella

83
Q

Measles with Posterior auricular LAD

A

Rubella

84
Q

Congenital rubella syndrome

A

PDA, congenital cataracts, sensorineural deafness, mental retardation

85
Q

(HIV) gag

A

p24, p7, p17

86
Q

(HIV) nucleocapsid

A

p24, p7

87
Q

(HIV) matrix

A

p17

88
Q

(HIV) pol

A

Reverse transcriptase, protease, integrase

89
Q

(HIV) transcribes RNA genome into DNA

A

Reverse transcriptase

90
Q

(HIV) cleaves precursor polypeptides

A

Protease

91
Q

(HIV) integrates viral DNA into host cell DNA

A

Integrase

92
Q

(HIV) env

A

gp120, gp41

93
Q

(HIV) attachment to CD4 protein

A

gp120

94
Q

(HIV) antigenicity changes rapidly

A

gp120

95
Q

(HIV) fusion with host cell

A

gp41

96
Q

(HIV) activation of transcription of viral genes

A

tat

97
Q

(HIV) transport of late mRNAs to cytoplasm

A

rev

98
Q

(HIV) decreases CD4 and class I MHC proteins (MUST KNOW!!!)

A

nef

99
Q

(HIV) enhances virion release

A

vpu

100
Q

(HIV) enhances hypermutation

A

vif

101
Q

(HIV) transport in nondividing cells

A

vpr

102
Q

HIV acquired through sexual intercourse, blood, or perinatally

A

Phase 0-Infection

103
Q

Rapid viral replication but HIV test negative

A

Phase 1-Window period

104
Q

Peak of viral load, positive HIV test, mild flu-like illness, lasting for 1-2 weeks

A

Phase 2-Seroconversion

105
Q

Asymptomatic, CD4 goes down, lasts for 1-15 years

A

Phase 3-Latent period

106
Q

CD4 500-200, lasts for 5 years, mild mucocutaneous, dermatologic and hematologic illnesses

A

Phase 4-Early symptomatic

107
Q

CD4 less than 200, lasts 2 years, AIDS defining illnesses develop

A

Phase 5-AIDS

108
Q

CD4 less than 500

A

M. tuberculosis, HSV, C. albicans, HHV-8

109
Q

CD4 less than 200

A

P. jiroveci, T. gondii, C. neoformans, C. immitis, C. parvum

110
Q

CD4 less than 50

A

M. avium, H. capsulatum, CMV

111
Q

MCC of death in HIV

A

Disseminated tuberculosis

112
Q

MCC of blindness in HIV

A

CMV retinitis

Microbiology and Parasitology (6 decks)

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