3 - Repair Flashcards
What describes excessive collagen deposition due to chronic inflammation (kidney, lungs, liver) or after necrosis (myocardial infarction)?
fibrosis
What describes fibrosis in a tissue space with an inflammatory exudate?
Organization
What do cyclins activate that leads to cell division?
CDKs (cyclin-dependent kinases)
What stops the cell cycle?
CDK inhibitors
What stimulates Angiogenesis in scar formation?
Vascular Endothelial Growth Factor (VEGF)
What stimulates migration and proliferation of fibroblasts; fibroblasts to make collagen in scar formation?
Fibroblast Growth Factor 2 (FGF)
Tissue created from blood and fibroblasts in scar formation is referred to as?
Granulation Tissue
What Scar Formation GF, in both acute and chronic inflammation, stimulates production of and inhibits breakdown of ECM; Ends inflammatory response?
TGF-beta
What Scar Formation GF is involved in migration and proliferation of fibroblasts and SM cells?
PDGF (platelet-derived growth factor)
What Scar Formation GF is involved in fibroblast migration?
FGF
What Scar Formation GF, stimulates collagen synthesis and fibroblast migration?
2 cytokines: IL-1, IL-13
In Remodeling what enzymes are released as inactive precursors, and activated by proteases at the site of injury?
MMPs
What inhibits MMPs?
Tissue Inhibitors of Metalloproteinases (TIMPs)
What enters first in the repair sequence?
PMNs (neutrophils)
How does steroid use impair wound healing?
inhibits TGF-beta
- so no stimulation of production of ECM and the inhibition of ECM breakdown; no longer end the inflammatory response
