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Mercy CLS 6: Hematology > 3) RBC development > Flashcards

3) RBC development Flashcards

1
Q

erythron

A

total population of mature erythrocytes and their precursors in blood, bone marrow and other sites

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2
Q

differentiations of erythropoiesis

A

CFU-GEMM + IL-3, GM-CSF →
CFU-EMk + IL-3, GM-CSF →
BFU-E + IL-3, GM-CSF →
CFU-E + EPO →
rubriblast

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3
Q

at CFU-E stage, cells develop…

A

Rh antigens and EPO receptors

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4
Q

Stephenson

A

discovered CFU-E

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5
Q

Axelrad

A

discovered BFU-E

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6
Q

in the bone marrow
difficult to ID morphologically

A

RBC precursors/progenitors

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7
Q

insensitive to EPO

A

BFU-E

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8
Q

changes that occur as erythrocytes develop

A
  1. cell volume ↓
  2. chromatin condenses
  3. nucleoli disappear
  4. RNA is lost (↓ blue)
  5. hemoglobin is produced (↑ red)
  6. mitochondria are lost
  7. nucleus is ejected
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9
Q

list both terminologies of morphologically identifiable RBCs, and how long they live (6)

A
  1. Rubriblast —Pronormoblast (12 hours)
  2. Prorubricyte —Basophilic normoblast (20 hours)
  3. Rubricyte —Polychromatophilic normoblast (30 hours)
  4. Metarubricyte —Orthochromatic normoblast (48 hours)
  5. Reticulocyte (diffusely basophilic) —Polychromatophilic erythrocyte (2-3 days marrow, 1-2 days blood)
  6. Mature RBC (120 days)
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10
Q

final RBC stage with nucleus

A

metarubricyte/orthrochromatic normoblast

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11
Q

final RBC stage capable of division

A

rubricyte/polychromatophilic normoblast

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12
Q

—– RBCs are produced from a single rubriblast

A

16

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13
Q

EPO is a ————

A

glycoprotein hormone

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14
Q

erythropoiesis occurs over about —– days in response to EPO

A

5

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15
Q

appearance of Fe-deficient cells

A

poorly hemoglobinized
scanty ragged cytoplasm
more basic stain (blue)

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16
Q

megaloblastic development results from…

A

folate & B12 deficiency
required for DNA synthesis/nucleus development

17
Q

appearance of megaloblastic cells

A

large
increased amount of hemoglobin
asynchrony of nucleus/cytoplasm development

18
Q

examples of changes to cells in megaloblastic development in marrow and PB

A

Marrow
- increased cell size
- decreased NC ratio
- smooth nuclear chromatin
- asynchronous development

Peripheral smear
- hypersegmentation of WBCs
- karyorrhexis
- giant-band neutrophils
- macro-ovalocytes
- Howell Jolly bodies

19
Q

5 cells or more with 5 lobes or more

A

hypersegmentation
megaloblastic

20
Q

fragmented WBC nucleus

A

karyorrhexis

21
Q

inclusions of DNA pieces in RBCs

A

Howell Jolly bodies

22
Q
A

karyorrhexis

23
Q
A

Howell Jolly bodies

24
Q
A

giant band neutrophil

25
Q
A

hypersegmented neutrophil

26
Q
A

macro-ovalocyte

Mercy CLS 6: Hematology (25 decks)

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