15) Lymphocytes & non-malignant lymphocyte disorders

Question 1

differentiation of stem cell → lymphocyte

Answer 1

• stem cell
• CLP
• lymphoblast
• prolymphocyte
• mature lympocyte

Question 2

15% of all lymphs

Answer 2

NK cells

Question 3

large lymph with pale cytoplasm and red granules

Answer 3

NK cell

Question 4

2 phases of lymphopoiesis

Answer 4

antigen independent (in primary lymph tissue)

antigen dependent (in secondary lymph tissue)

Question 5

makes immunocompetent lymphs

Answer 5

antigen independent lymphopoiesis

Question 6

very dark blue blast

Answer 6

lymphoblast

Question 7

large, distinct nucleoli
cytoplasm getting lighter blue

Answer 7

prolymphocyte

Question 8

extremely variable cells

Answer 8

lymphs

Question 9

nucleoli in mature lymphs may be seen in…

Answer 9

CSF
body fluids

Question 10

sky blue cytoplasm

Answer 10

lymphs

Question 11

may have countable granules, or rare vacuoles

Answer 11

lymphs

Question 12

cytoplasm scalloped around RBCs
blue edges

Answer 12

reactive lymph

Question 13

reactive lymph may be a precursor to…

Answer 13

immunoblast

Question 14

huge lymph with fine chromatin and prominent nucleoli

Answer 14

immunoblast

Question 15

salami nucleus

Answer 15

immunoblast

Question 16

immunoblasts are found in…

Answer 16

secondary lymph tissues

Question 17

B cells + antigen → ———– → ———–

Answer 17

plasmacytoid cells
plasma cells

Question 18

eccentric nucleus with paranuclear unstained area

Answer 18

plasma cell

Question 19

null cells

Answer 19

NK cells

Question 20

function of NK cells

Answer 20

kill tumor cells, virally infected cells, cells coated with IgG

Question 21

plasma cells with reddish-purple cytoplasm

contain more Ig than usual

Answer 21

flame cells

Question 22

flame cells seen in….

Answer 22

MM

Question 23

grape cells
plasma cells filled with dark globules

Answer 23

Mott cells

Question 24

Russell bodies are found in ——— cells

Answer 24

Mott
(grape)

Question 25

Mott cells’ globules are filled with —— and are found in…

Answer 25

Ig

plasmacyte hyperplasia
parasitic infections
malignancies

Question 26

nuclear membrane inclusions found in neoplastic plasma cells

Answer 26

Dutcher bodies

Question 27

look like very bright nucleoli

Answer 27

Dutcher bodies

Question 28

60-80% of PB lymphs are…

Answer 28

T-cells

Question 29

about 20% of lymphs live only…

Answer 29

few hours to 5 days

most live months to years

Question 30

adult relative & absolute lymphocytosis

Answer 30

> 40%
4 x 10^3

Question 31

———megaly is common when lymphs are actively proliferating in response to infection

Answer 31

splenomegaly

Question 32

causes absolute lymphocytosis to lead to ↑ WBC

Answer 32

• B. pertussis
• infectious mono
• infectious lymphocytosis
• lymphocytic leukemia
• CMV

Question 33

> 50% lymphs, with >20% being atypical

Answer 33

EBV

Question 34

rarely, —– can cause an AIHI anti-i to develop

Answer 34

EBV

Question 35

intracellular protozoan infecting all cells but RBCs

Answer 35

Toxoplama gondii

Question 36

flower shape nuclei

Answer 36

toxoplasmosis lymphs

Question 37

———- can be a complication in immcomp toxoplasmosis pts

Answer 37

hemolytic anemia

Question 38

thought to infect neutrophils
many reactive lymphs
negative heterophile Ab test

Answer 38

CMV

Question 39

possibly caused by coxsackie A or adenovirus

Answer 39

infectious lymphocytosis

Question 40

lymphocytosis with no reactive lymphs (60-97% small normal lymphs)

Answer 40

infectious lymphocytosis

Question 41

lymphocytosis with small lymphs having very dense chromatin

Answer 41

B. pertussis

Question 42

butt nuceli in lymphs

Answer 42

B. pertussis

Question 43

plasma cells in PB

Answer 43

plasmacytosis

Question 44

——— infections commonly show plasmacytosis

Answer 44

rubeola

Question 45

adult absolute lymphocytopenia

Answer 45

<1.0 x 10^3

Question 46

most common cause of lymphocytopenia

Answer 46

malnutrition
T-cell depletion