15) Lymphocytes & non-malignant lymphocyte disorders Flashcards
differentiation of stem cell → lymphocyte
- stem cell
- CLP
- lymphoblast
- prolymphocyte
- mature lympocyte
15% of all lymphs
NK cells
large lymph with pale cytoplasm and red granules
NK cell
2 phases of lymphopoiesis
antigen independent (in primary lymph tissue)
antigen dependent (in secondary lymph tissue)
makes immunocompetent lymphs
antigen independent lymphopoiesis
very dark blue blast
lymphoblast
large, distinct nucleoli
cytoplasm getting lighter blue
prolymphocyte
extremely variable cells
lymphs
nucleoli in mature lymphs may be seen in…
CSF
body fluids
sky blue cytoplasm
lymphs
may have countable granules, or rare vacuoles
lymphs
cytoplasm scalloped around RBCs
blue edges
reactive lymph
reactive lymph may be a precursor to…
immunoblast
huge lymph with fine chromatin and prominent nucleoli
immunoblast
salami nucleus
immunoblast
immunoblasts are found in…
secondary lymph tissues
B cells + antigen → ———– → ———–
plasmacytoid cells
plasma cells
eccentric nucleus with paranuclear unstained area
plasma cell
null cells
NK cells
function of NK cells
kill tumor cells, virally infected cells, cells coated with IgG
plasma cells with reddish-purple cytoplasm
contain more Ig than usual
flame cells
flame cells seen in….
MM
grape cells
plasma cells filled with dark globules
Mott cells
Russell bodies are found in ——— cells
Mott
(grape)
Mott cells’ globules are filled with —— and are found in…
Ig
plasmacyte hyperplasia
parasitic infections
malignancies
nuclear membrane inclusions found in neoplastic plasma cells
Dutcher bodies
look like very bright nucleoli
Dutcher bodies
60-80% of PB lymphs are…
T-cells
about 20% of lymphs live only…
few hours to 5 days
most live months to years
adult relative & absolute lymphocytosis
> 40%
4 x 10^3
———megaly is common when lymphs are actively proliferating in response to infection
splenomegaly
causes absolute lymphocytosis to lead to ↑ WBC
- B. pertussis
- infectious mono
- infectious lymphocytosis
- lymphocytic leukemia
- CMV
> 50% lymphs, with >20% being atypical
EBV
rarely, —– can cause an AIHI anti-i to develop
EBV
intracellular protozoan infecting all cells but RBCs
Toxoplama gondii
flower shape nuclei
toxoplasmosis lymphs
———- can be a complication in immcomp toxoplasmosis pts
hemolytic anemia
thought to infect neutrophils
many reactive lymphs
negative heterophile Ab test
CMV
possibly caused by coxsackie A or adenovirus
infectious lymphocytosis
lymphocytosis with no reactive lymphs (60-97% small normal lymphs)
infectious lymphocytosis
lymphocytosis with small lymphs having very dense chromatin
B. pertussis
butt nuceli in lymphs
B. pertussis
plasma cells in PB
plasmacytosis
——— infections commonly show plasmacytosis
rubeola
adult absolute lymphocytopenia
<1.0 x 10^3
most common cause of lymphocytopenia
malnutrition
T-cell depletion
