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Mercy CLS 6: Hematology > 21) CLL > Flashcards

21) CLL Flashcards

1
Q

patients with widespread ——— often have worse CLL prognosis

A

lymphoma

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2
Q

the ann arbor staging system is used for…

A

malignant lymphoma

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3
Q

CLL/SLL

A

chronic lymphocytic leukemia/small lymphocytic leukemia

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4
Q

different clinical manifestations of one disease entity

A

CLL/SLL

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5
Q

CLL presents with…
SLL presents with…

A

PB lymphocytosis
lymphadenopathy

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6
Q

sustained absolute monoclonal lymphocytosis
(>5 x 10^3)

A

CLL/SLL

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7
Q

lymphocytosis + smudge cells

A

CLL/SLL

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8
Q

if lymphocytosis is <5 x 10^3, it’s not CLL, its…

A

B-cell monoclonal lymphocytosis
no chemo yet

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9
Q

CD5
CD20
CD23
CD200
LEF-1 +

A

CLL/SLL

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10
Q

CD5
CD23=
FMC-7 +
cyclin D1 +

A

mantle cell lymphoma

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11
Q

CLL/SLL must be distinguished from…

how?

A

mantle cell lymphoma

MCL is CD23=, FMC-7+, LEF-1=

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12
Q

t(11;14)

A

mantle cell lymphoma

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13
Q

Richter’s transformation

A

transformation from CLL → aggressive large B-cell lymphoma

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14
Q

anti-CD20 mAbs

A

used to tx CLL/SLL

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15
Q

ibrutinib

A

used to tx CLL/SLL

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16
Q

B-PLL

A

B-cell prolymphocytic leukemia

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17
Q

B-PLL survival

A

7.5 months

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18
Q

> 55% prolymphocytes
marked lymphocytosis

A

B-PLL

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19
Q

HCL

A

hairy cell leukemia

20
Q

uncommon B-cell neoplasm more common in males (7:1)

A

HCL

21
Q

lymph disorder
massive splenomegaly
no lymphocytosis
pancytopenia

A

HCL

22
Q

how is HCL different from CLL?

A

pancytopenia

23
Q

other name for MM

A

plasma cell neoplasm

24
Q

M-spike
functional hypogammaglobulinemia
Bence Jones protein

A

MM/plasma cell neoplasm

25
Q

4 types of plasma cell neoplasms

A
  • symptomatic MM
  • asymptomatic MM (smoldering)
  • monoclonal gammopathy of undetermined significance
  • plasmacytoma
26
Q

M spike >30 g/L
no organ/tissue damage
BM clonal plasma cells >10%

A

asymptomatic/smoldering MM

27
Q

M spike <30 g/L
no organ/tissue damage
BM clonal plasma cells <10%

A

MGUS

28
Q

solitary collection of clonal plasma cells
may have M spike

A

plasmacytoma

29
Q
A

MM
hypercalcemia
renal insufficiency
anemia
lytic bone lesions

30
Q
A

MM

31
Q

MM patients often present with…

A

pathologic fracture

32
Q

rouleaux
Mott cells
flame cells
Dutcher bodies
PB stains dark blue background (protein)

A

MM

33
Q

MM survival (symptomatic)

A

3-4 years

34
Q

<65 yo: high-dose chemo + SCT
>65 yo: melphalan chemo + prednisone

A

MM tx

35
Q

heterogeneous morphology
histiocytes, plasma cells, eos mixed in

A

peripheral T-cell lymphoma

36
Q

usually CD4+/CD8=

complex karyotype

A

peripheral T-cell lymphoma

37
Q

marked lymphocytosis
skin lesions
hepatosplenomegaly
variable morphology

A

peripheral T-cell prolymphocytic leukemia

38
Q

modest but prolonged lymphocytosis
must differentiate from reactive lymphocytosis
usually requires evidence of abnormal phenotype/clonality

A

T-cell large granular lymphocytic leukemia

39
Q

the only frequent T-cell lymphoma, with a good prognosis

A

T-cell large granular lymphocytic leukemia

40
Q

associated with RA

A

T-cell large granular lymphocytic leukemia

41
Q

Felty’s syndrome (RA, splenomegaly, neutropenia) associated with…

A

T-cell large granular lymphocytic leukemia

42
Q

CD4=/CD8+

A

T-cell large granular lymphocytic leukemia

43
Q

T-cell large granular lymphocytic leukemia requires ….. to dx

A

molecular studies on clonal T-cell receptor rearrangement

44
Q

ATLL

A

adult t-cell leukemia/lymphoma

45
Q

caused by HTLV-1

A

adult t-cell leukemia/lymphoma

46
Q

hyperlobated, cloverleaf nuclei

A

adult t-cell leukemia/lymphoma

47
Q

FoxP3

A

adult t-cell leukemia/lymphoma

Mercy CLS 6: Hematology (25 decks)

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