3-Psychosocial Chapter

Question 1

What is Pharmacogenomics?

Answer 1

pharmacogenetics and variation among individuals in drug targets and disease mechanism

Question 2

What is a robust clinical response?
Cyp enzymes fast/slow?
High/low levels of drug in body?

Answer 2

causes desired effects
CYP enzymes dont metabolize as quickly
high levels of drug in body

Question 3

What is a intolerable clinical response? What is the level of drug?

Answer 3

high levels of drug and are getting adverse reax

Question 4

What is no clinical response:

Enzymes fast/slow?

Answer 4

enzymes are fast

gets rid of drug before it can do any work

Question 5

What are some factors affecting pharmacodynamics and pharmacokinetics?

Answer 5

Drug metabolizing enzymes, transporters, and target cells

Question 6

What is the reason behind genetic variations in effectiveness of drugs?

Answer 6

Mostly due to acetylation of enzymes

Question 7

Absorption rate in pediatric patients: GI/oral

Answer 7

variable

Question 8

Absorption rate in pediatric patients: IM

Answer 8

variable

Question 9

Absorption rate in pediatric patients: Percutaneous/subQ

Answer 9

enhanced absorption

if they have a lot of fatty tissue

Question 10

Absorption rate in pediatric patients: Distribution High/low?

Answer 10

high

Question 11

Absorption rate in pediatric patients: Through the blood/brain barrier High/low?

Answer 11

high- not as tight

Question 12

Absorption rate in pediatric patients: Kidneys

Answer 12

dont excrete as well

Question 13

Absorption rate in pediatric patients: Liver

Answer 13

Dont metabolize as well

Question 14

How is pediatric drug dosing carried out?

Answer 14

body surface area

or body weight