3: gfr & rbf

Question 1

glomerular cap membrane is dif than others in the body bc there are:

Answer 1

3 layers instead of usual 2

endo, BM, epi cell layer

Question 2

kidney has selective filtration due to ___ size

Answer 2

pore

Question 3

glomerular cap membrane endothelium is ___ charged, and in the BM, proteoglycans have a strong neg charge which ___ passage of proteins

Answer 3

negatively

inhibits

Question 4

epithelium of glomerular cap membrane is NEG charged to INHIBIT __ __ leakage

Answer 4

plasma protein

Question 5

body manages pressure differences via control of the smooth muscle of the ____ arteriole and ___ arteriole

Answer 5

afferent

efferent

Question 6

the volume of blood plasma delivered to the kidneys per unit time (us. ml/min)

Answer 6

renal plasma flow (RPF)

Question 7

proportion of the fluid reaching the kidneys that passes into the renal tubules

Answer 7

filtration fraction (FF)

Question 8

RBF x FF =

Answer 8

GFR

Question 9

GFR / FF =

Answer 9

RBF

Question 10

GFR / RBF =

Answer 10

FF

Question 11

body can INCREASE GFR by altering what 2 things?

Answer 11

RPF ( increase CO, dilate afferent arterioles)

FF (contract efferent arteriole)

Question 12

Kf is known as the

Answer 12

capillary filtration coefficient

Question 13

Kf x net filtration pressure =

Answer 13

GFR

Question 14

net filtration pressure:

• hydrostatic P inside __ __
• hydrostatic P inside __ __
• colloid osmotic P of glom cap __ __
• colloid osmotic P of the __ in bowman’s capsule

Answer 14

glomerular capillaries
bowman’s capsule
plasma proteins
proteins

Question 15

if you decrease capillary filtration coefficient (Kf), glomerular filtration rate (GFR) will ____

Answer 15

decrease

Question 16

if you INCREASE cowman’s capsule pressure, you ____ GFR

Answer 16

decrease

Question 17

if you INCREASE glomerular colloid osmotic pressure, GFR will ____

Answer 17

decrease

Question 18

if you decrease or increase glomerular hydrostatic pressure, ___ will decrease or increase along with it

Answer 18

GFR

Question 19

___ ___ resistance can be altered to affect glomerular capillary hydrostatic pressure

Answer 19

afferent arteriolar

Question 20

___ afferent arterioles decreases GCHP which decreases GFR

___ afferent arterioles increases GCHP which increases GFR

Answer 20

constricting

dilating

Question 21

when constricting ___ arterioles, GCHP increases, which slightly increases GFR

Answer 21

efferent

Question 22

strong ___ activation decreases GFR

Answer 22

sympathetic

Question 23

__ & __ decrease GFR

Answer 23

epinephrine

norepinephrine

Question 24

___ is seen in disease states and causes renal constriction and decreased GFR

Answer 24

endothlin

Question 25

____, a powerful renal vasoconstrictor maintains GFR

Answer 25

angiotensin II

Question 26

__ & _ are vasodilators that increases renal blood flow and GFR

Answer 26

prostaglandins

bradykinin

Question 27

___ feedback is a mech linking Na concentration w/ renal artery resistance that ensures a constant delivery of NaCl to distal tubules

Answer 27

tubuloglomerular

Question 28

the ability of the indv BV in the bod to resist stretching during increased arterial pressure is the ___ mechanism

Answer 28

myogenic

Question 29

for some solutes, excretion rate =

-eg Na, bicarb, Cl-

Answer 29

filtration rate - reabsorption rate (but non-zero)

Question 30

for some solutes, if excretion rate = __, there is no excretion in the urine, all is reabsorbed from tubules into the blood
-eg: ___ substances in the blood

Answer 30

0

nutritional (AA & glucose)

Question 31

some solutes, excretion rate =

- organic acids/bases, foreign substances, drugs

Answer 31

filtration rate + secretion rate

Question 32

when the neg charge of the glom cap membrane is compromised, the __ __ loses its electrical charge

Answer 32

basement membrane