3: gfr & rbf Flashcards
glomerular cap membrane is dif than others in the body bc there are:
3 layers instead of usual 2
endo, BM, epi cell layer
kidney has selective filtration due to ___ size
pore
glomerular cap membrane endothelium is ___ charged, and in the BM, proteoglycans have a strong neg charge which ___ passage of proteins
negatively
inhibits
epithelium of glomerular cap membrane is NEG charged to INHIBIT __ __ leakage
plasma protein
body manages pressure differences via control of the smooth muscle of the ____ arteriole and ___ arteriole
afferent
efferent
the volume of blood plasma delivered to the kidneys per unit time (us. ml/min)
renal plasma flow (RPF)
proportion of the fluid reaching the kidneys that passes into the renal tubules
filtration fraction (FF)
RBF x FF =
GFR
GFR / FF =
RBF
GFR / RBF =
FF
body can INCREASE GFR by altering what 2 things?
RPF ( increase CO, dilate afferent arterioles)
FF (contract efferent arteriole)
Kf is known as the
capillary filtration coefficient
Kf x net filtration pressure =
GFR
net filtration pressure:
- hydrostatic P inside __ __
- hydrostatic P inside __ __
- colloid osmotic P of glom cap __ __
- colloid osmotic P of the __ in bowman’s capsule
glomerular capillaries
bowman’s capsule
plasma proteins
proteins
if you decrease capillary filtration coefficient (Kf), glomerular filtration rate (GFR) will ____
decrease
if you INCREASE cowman’s capsule pressure, you ____ GFR
decrease
if you INCREASE glomerular colloid osmotic pressure, GFR will ____
decrease
if you decrease or increase glomerular hydrostatic pressure, ___ will decrease or increase along with it
GFR
___ ___ resistance can be altered to affect glomerular capillary hydrostatic pressure
afferent arteriolar
___ afferent arterioles decreases GCHP which decreases GFR
___ afferent arterioles increases GCHP which increases GFR
constricting
dilating
when constricting ___ arterioles, GCHP increases, which slightly increases GFR
efferent
strong ___ activation decreases GFR
sympathetic
__ & __ decrease GFR
epinephrine
norepinephrine
___ is seen in disease states and causes renal constriction and decreased GFR
endothlin
____, a powerful renal vasoconstrictor maintains GFR
angiotensin II
__ & _ are vasodilators that increases renal blood flow and GFR
prostaglandins
bradykinin
___ feedback is a mech linking Na concentration w/ renal artery resistance that ensures a constant delivery of NaCl to distal tubules
tubuloglomerular
the ability of the indv BV in the bod to resist stretching during increased arterial pressure is the ___ mechanism
myogenic
for some solutes, excretion rate =
-eg Na, bicarb, Cl-
filtration rate - reabsorption rate (but non-zero)
for some solutes, if excretion rate = __, there is no excretion in the urine, all is reabsorbed from tubules into the blood
-eg: ___ substances in the blood
0
nutritional (AA & glucose)
some solutes, excretion rate =
- organic acids/bases, foreign substances, drugs
filtration rate + secretion rate
when the neg charge of the glom cap membrane is compromised, the __ __ loses its electrical charge
basement membrane
