3: Derm Malignancies Flashcards
Which type of basal cell carcinoma? Pigmented, nodular, micronodular, or morpheaform/sclerosing?
Contain melanin that appears speckled, brown, blue, or black (darker skin types), and may resemble dysplastic nevi or melanoma.
Pigmented BCC
Which type of basal cell carcinoma? Pigmented, nodular, micronodular, or morpheaform/sclerosing?
Pale white to yellow, waxy plaques with indistinct margins whose cells can extend up to 7 mm beyond the clinical border.
Morpheaform/Sclerosing BCC
What are treatment options for low-risk squamous cell carcinoma (3)?
- Screenings
- Nodal Assessment
- Wide local excision
Increasingly common malignancies of the melanocytes of the skin, eyes, and mucosa.
Malignant Melanomas
T/F Basal cell carcinoma is usually flat.
False. It can be superficial, flat, atrophic, pearly pink to red.
When does actinic keratosis require a biopsy (2)?
- Unresponsive to treatment
2. Recurrent
What are the ABCDEs of malignant melanomas?
Asymmetry Border irregularity Color variegation Diameter >6 mm Evolution
Actinic keratosis is a precursor to what cancer?
Squamous Cell Carcinoma (SCC)
T/F Squamous cell carcinoma is at risk for metastasis.
True. At risk for metastasis if large, recurrent, or poorly differentiated.
Merkel cell carcinoma should be sent for shave or punch biopsy. They often recur in _____ months, have _____, and _____.
They often recur in 8-12 months, have nodal involvement, and metastasize.
Smooth, pearly, translucent, pink lesions with telangiectasias.
Basal Cell Carcinoma
Which subtype of melanoma: superficial spreading, nodular, lentiginous, or acral?
70–80%, F>M, trunk and extremities, greater than 6 mm, flat, asymmetric, varying coloration.
Superficial Spreading Melanoma
What is the Breslow staging threshold for sending to dermatologic surgeon vs surgical oncologist with malignant melanoma?
Dermatology = Breslow <0.75 mm Onoclogy = Breslow >0.75 mm
Which subtype of melanoma: superficial spreading, nodular, lentiginous, or acral?
10–15%, extremities, raised, brown-black, rapidly growing papules.
Nodular Melanoma
Uncommon, aggressive neuroendocrine carcinomas with possible infectious component, and typically affect people over age 65.
Merkel Cell Carcinoma
What is the treatment for actinic keratosis (6)?
- Imiquimod
- Cryotherapy
- 5-fluorouracil
- Photodynamic therapy
- Laser
- Sunscreen
Actinic keratosis can spontaneously regress, but about _____% of lesions progress to SCC.
15%
Lesions can be pink, dull red, poorly defined, dome shaped, and scaly with yellow keratin.
Squamous Cell Carcinoma