3: Asthma Medications Flashcards

1
Q

3 classes of rescue meds.

A

SABA
Anticholinergics
Systemic corticosteroids

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2
Q

Peak effect of SABA.

A

15-30 minutes (wears off in 4-6 hours).

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3
Q

Is this a SABA, anticholinergic, systemic corticosteroid, ICS, immunomodulator, leukotriene modifier, LABA, or methylxanthine?
Albuterol sulfate

A

SABA

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4
Q

Is this a SABA, anticholinergic, systemic corticosteroid, ICS, immunomodulator, leukotriene modifier, LABA, or methylxanthine?
Proventil

A

SABA

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5
Q

Is this a SABA, anticholinergic, systemic corticosteroid, ICS, immunomodulator, leukotriene modifier, LABA, or methylxanthine?
Ventolin

A

SABA

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6
Q

Is this a SABA, anticholinergic, systemic corticosteroid, ICS, immunomodulator, leukotriene modifier, LABA, or methylxanthine?
Levalbuterol

A

Nonracemic SABA

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7
Q

Is this a SABA, anticholinergic, systemic corticosteroid, ICS, immunomodulator, leukotriene modifier, LABA, or methylxanthine?
Xopenex

A

Nonracemic SABA

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8
Q

Is this a SABA, anticholinergic, systemic corticosteroid, ICS, immunomodulator, leukotriene modifier, LABA, or methylxanthine?
Ipratropium

A

Anticholinergic

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9
Q

Is this a SABA, anticholinergic, systemic corticosteroid, ICS, immunomodulator, leukotriene modifier, LABA, or methylxanthine?
Atrovent

A

Anticholinergic

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10
Q

Is this a SABA, anticholinergic, systemic corticosteroid, ICS, immunomodulator, leukotriene modifier, LABA, or methylxanthine?
Prednisone

A

Systemic Steroid

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11
Q

Is this a SABA, anticholinergic, systemic corticosteroid, ICS, immunomodulator, leukotriene modifier, LABA, or methylxanthine?
Prednisolone

A

Systemic Steroid

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12
Q

Is this a SABA, anticholinergic, systemic corticosteroid, ICS, immunomodulator, leukotriene modifier, LABA, or methylxanthine?
Methylprednisolone

A

Systemic Steroid

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13
Q

Is this a SABA, anticholinergic, systemic corticosteroid, ICS, immunomodulator, leukotriene modifier, LABA, or methylxanthine?
Dexamethasone

A

Systemic Steroid

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14
Q

6 classes of long-term control meds.

A
ICS
Cromolyn Sodium and Nedocromil
Immunomodulators
Leukotriene Modifiers
LABA
Methylxanthines
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15
Q

Is this a SABA, anticholinergic, systemic corticosteroid, ICS, immunomodulator, leukotriene modifier, LABA, or methylxanthine?
Salmeterol

A

LABA

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16
Q

Is this a SABA, anticholinergic, systemic corticosteroid, ICS, immunomodulator, leukotriene modifier, LABA, or methylxanthine?
Serevent

A

LABA

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17
Q

Is this a SABA, anticholinergic, systemic corticosteroid, ICS, immunomodulator, leukotriene modifier, LABA, or methylxanthine?
Fluticasone

A

ICS

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18
Q

Is this a SABA, anticholinergic, systemic corticosteroid, ICS, immunomodulator, leukotriene modifier, LABA, or methylxanthine?
Flovent Diskus

A

ICS

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19
Q

Is this a SABA, anticholinergic, systemic corticosteroid, ICS, immunomodulator, leukotriene modifier, LABA, or methylxanthine?
Budesonide

A

ICS

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20
Q

Is this a SABA, anticholinergic, systemic corticosteroid, ICS, immunomodulator, leukotriene modifier, LABA, or methylxanthine?
Pulmicort Flexhaler

A

ICS

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21
Q

Is this a SABA, anticholinergic, systemic corticosteroid, ICS, immunomodulator, leukotriene modifier, LABA, or methylxanthine?
Respules

22
Q

Is this a SABA, anticholinergic, systemic corticosteroid, ICS, immunomodulator, leukotriene modifier, LABA, or methylxanthine?
Montelukast

A

Leukotriene Modifier

23
Q

Is this a SABA, anticholinergic, systemic corticosteroid, ICS, immunomodulator, leukotriene modifier, LABA, or methylxanthine?
Singulair

A

Leukotriene Modifier

24
Q

Is this a SABA, anticholinergic, systemic corticosteroid, ICS, immunomodulator, leukotriene modifier, LABA, or methylxanthine?
Theophylline

A

Methylxanthine

25
What class is omalizumab?
Monoclonal Antibody
26
Is this a SABA, anticholinergic, systemic corticosteroid, ICS, immunomodulator, leukotriene modifier, LABA, or methylxanthine? Symbicort
Combined ICS/LABA (Budesonide/Formoterol)
27
Is this a SABA, anticholinergic, systemic corticosteroid, ICS, immunomodulator, leukotriene modifier, LABA, or methylxanthine? Advair
Combined ICS/LABA (Salmeterol/Fluticasone)
28
Prolonged use of albuterol is associated with what?
Tachyphylaxis d/t beta2-receptor downregulation and receptor hyposensitivity.
29
Nonracemic form of albuterol offers a significant reduction in which adverse effects?
Muscle tremors Tachycardia Hyperglycemia Hypokalemia
30
T/F Levalbuterol is effective in smaller doses than albuterol.
True. And dose may be doubled in acute severe episodes.
31
SABAs are used for what 2 situations?
Treat bronchospasm in acute episodes. | Prevent bronchospasm in exercise-induced asthma.
32
Acts as bronchodilator by inhibiting muscarinic receptors and reduces vagal tone of airways.
Anticholinergics
33
Adjuvant therapy with SABA for treatment of acute exacerbations.
Anticholinergics
34
Works to inhibit secretions from serous and seromucous glands lining nasal mucosa.
Anticholinergic (applied locally)
35
Used for a short course (3-10 days) to gain control of poorly controlled episodes.
Systemic Corticosteroids
36
When are systemic corticosteroids used long-term?
Used for long-term prevention of symptoms in severe persistent asthma as well as for suppression, control, and reversal of inflammation.
37
What does a systemic corticosteroid do for SABAs?
It reverses the subsensitivity and downregulation of beta2 receptors from frequent and repetitive use of SABAs.
38
Which systemic corticosteroid is not associated with vomiting?
Dexamethasone
39
Preventive treatment of nocturnal asthma or exercise-induced asthmatic symptoms.
LABAs
40
T/F LABAs are stand-alone meds for both asthma and COPD.
False. They are never to be used alone in asthma. They are only used if other meds do not control asthma and must be used in combination with other meds.
41
Long-term control of symptoms. Suppression, control, and reversal of inflammation.
ICSs
42
Most potent anti-inflammatory agents but are least likely to cause adverse effects b/c poorly absorbed systemically.
ICSs
43
Adverse effects of ICSs.
Oral candidiasis Dysphonia Reflex cough Bronchospasm
44
How are adverse effects of ICS minimized?
With spacer and MDI.
45
Block late asthmatic response to allergens. Reduce airway hyperresponsiveness. Inhibit cytokine production, adhesion protein activation, and inflammatory cell migration and activation. Reverse beta2-receptor downregulation and subsensitivity.
ICS
46
How do leukotrienes cause problems?
+ bronchospasm, increased vascular permeability, mucosal edema, and inflammatory cells.
47
Long-term control and prevention of symptoms, especially nocturnal symptoms.
Methylxanthines
48
Causes bronchodilation and minimal anti-inflammatory properties. Less effective than ICSs. Potential toxicity, so monitor serum concentrations. Used infrequently.
Methylxanthines
49
Moderate-to-severe persistent asthma patients who react to perennial allergens. Symptoms are not controlled by inhaled corticosteroids.
Monoclonal Antibodies
50
Bind selectively to human IgE on the surface of mast cells and basophils.
Monoclonal Antibodies
51
This has a risk of severe allergic reaction and is only used in 12+ age group.
Omalizumab (Monoclonal Antibody)
52
Decrease asthma exacerbations when inhaled short-acting beta2-agonists and corticosteroids have failed.
Combined ICS/LABA