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Pharmacotherapy 1 > 3 - Asthma and COPD med short-acting > Flashcards

3 - Asthma and COPD med short-acting Flashcards

1
Q

inh’d SABAs

A

albuterol HFA
albuterol
levalbuterol HFA
levalbuterol

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2
Q

What are the DFs and approved age ranges for albuterol HFA?

A

MDI
aerosol powder inh

all ages

includes exacerbation dosing

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3
Q

What are the AEs for SABAs?

A

tachycardia
tremor
hypokalemia
irritability

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4
Q

What are clinical pearols for albuterol?

A

use >2x/d indicates poor control

may mix nebulizer soln w comolyn soln, budesonide inhalant susp, or ipratropium soln

in mild to mod exacerbations, MDI plu VHC is as effective as nebulizer w proper technique

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5
Q

What are the DFs and approved ages for albuterol (not HFA)?

A

nebulizer soln

all ages

includes exacerbation dosing

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6
Q

What is the DF for levalbuterol HFA and levalbuterol?

approved ages?

A

HFA: MDI
non-HFA: nebulizer soln

> 5 yoa

includes exacerbation dosing

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7
Q

What are clinical pearls for levalbuterol and levalb HFA?

A

reserved for pts who do not respond to alb for quick relief

nebulizer compatible w budesonide inhalant susp

levalbuterol admin’d in 1/2 the mg dos eof albterol provides comparable efficacy and safety

has not been evaluated by cont neb

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8
Q

What are the SAMAs?

A

ipratropium HFA = Atrovent
iptatroium (neb)
Ipratroium/albuterol (Combivent Respimat)
ipratroium /albuterol (neb)

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9
Q

What is the moa of SAMAs?

A

inhib cholinergic recpeotrs –> decr cGMP –> bronchodilation

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10
Q

What is the DF and approved ages for ipratroium?

A

HFA: MDI
neb soln

only for exacerbations <12 yo

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11
Q

What is the DF and approve ages for ipratropium/albuterol?

A

Combivent Respimat: MDI
neb

Combivent Respimat is used only in exac for <12 yoa
neb: all ages

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12
Q

What are the AEs of ipratropium?

A

dry mouth, urinary retention, infx, sinuisitis, bnchitis

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13
Q

What are clinical pearls for ipratropium?

A

used in combo w albuterol for asthma exac tx

may mix in ame nebulizer w albuterol

should nt be used as first-line therapy, should be aded to SABA therapy for sev exacerbations

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14
Q

What are clincial pearls for ipratropium/albuterol neb soln?

A

may be used up to 3 hr in initial management of severe exacerbations

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15
Q

What are the sys CSs?

A

methylprednisolone
prednisolone
prednisone
methylprednisolone acetate

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16
Q

What is the moa of sys CS?

A

decr inflammx

incr response to B2 Ag

17
Q

What is the DF and approved ages for metylprednisolone/prednisolone/prednisone?

A

tab only for methylprednisolone
pred’s are both tab and oral liquid

all ages for burst (40-60 mg/d po as single dose for 5 d)

18
Q

What is the DF and approved ages for methylprednisolone acetate?

A

repository inj

all ages

19
Q

What are AEs for sys CSs?

A 
short term use-hyperglycemia, 
incr'd appetite
fluid retention
demargination of WBCs
psychiatric disturbances
20
Q

What are CIs for syst CSs?

A

systemic fungal infx

admin of live vaccines if immunocompromised

21
Q

What are DI for syst CSs?

A

warfarin INF incr

decr efficacy of inactivated vaccines

22
Q

What are clinical pearls for syst CSs?

A

may be used w ICS if pt is already taking ICS before hospitalization
may be used for chornic therapy in both asthma (and COPD) only in severe stage

bursts effective for establishing control when initiating therapy or during period of gradual deterioration

inj may be used in place of burst if adherence is an issue or pt is vomitting

23
Q

What are addition meds for asthma exacerbations?

A

(normal SABAs, SAMAs, sys CSs)

system (SC) B2 ag: epi and terbutaline

mag sulfate

24
Q

What are clinical pearls concerning systemic B2 agonists?

A

no proven advantage of systemic therapy over aerosol

25
Q

Whtat are the systemic B2 ag used in treating asthma exacerbation.

A

epi

terbutaline

26
Q

What is the moa of mag sulfate in controlling asthma exacerbations?

A

SM relaxation through inhib of Ca influx into SM cells

27
Q

What is the DF of systemic B2 ags?

approved age?

A

SC inj

child and adult

28
Q

What is the Df of mag sulfate?

approved age?

A

IV

child and adult approved

29
Q

What are AEs of mag sulfate IV?

A

flushing
hypoTN
vasodilation

30
Q

What are CI for mag sulfate IV

A

heart block

can cause renal dysfxn

31
Q

What are clinical pearls for mag sulfate?

A

consider if pt remains in life threatening exac after 1 hr therapy

32
Q

meds by brand name

A

https://quizlet.com/201445677/asthma-and-copd-meds-by-brand-name-flash-cards/?new

33
Q

meds by class/AEs

A

https://quizlet.com/201444892/asthma-and-copd-medications-flash-cards/

Pharmacotherapy 1 (26 decks)

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