3 Anti-virals

Question 1

What is the structure of viruses?

Answer 1

Nucleic acid with proteins (coat and enzymes).

Question 2

What are the 8 steps of viral replication?

Answer 2

Virus attachment. Cell entry. Virus uncoating. Early protein production. Replication. Late protein production. Virus assembly. Virus release.

Question 3

Which polymerases are unique among viruses?

Answer 3

RNA to RNA (RNA viruses)

RNA to DNA (Retroviruses and Hep B)

Question 4

What are NRTI’s?

Answer 4

Nucleoside Reverse Transcriptase Inhibitor

Question 5

NRTI’s are analogues. What are the thymidine analogues?

Answer 5

Zidovudine, azidothymidine.

Question 6

Give two examples of non-nucleotide reverse transcriptase inhibitors.

Answer 6

Efavirenz

Nevirapine

Question 7

Give two examples of protease inhibitors.

Answer 7

Atazanavir. Darunavir.

Question 8

Give an example of a fusion inhibitor

Answer 8

Enfuviritide

Question 9

Give an example of an integrase inhibitor

Answer 9

Raltegravir

Question 10

Give an example of a chemokine receptor antagonist (CCR5).

Answer 10

Maraviroc

Question 11

What is HAART?

Answer 11

2 NRTIs + NNRTI
2 NRTIs + boosted PI

Switch of CD4 replication.

Question 12

Which HIV mutation confers resistance to Lamivudine?

Answer 12

M184V

Question 13

Which gene confers resistance to HIV?

Answer 13

CCR 5 delta 32

Question 14

What is Aciclovir and what is it used for?

Answer 14

Nucleoside analogue.

HSV. VZV.

Question 15

What is Ganciclovir used for?

Answer 15

Cytomegalovirus

Question 16

What is Ribavirin used for?

Answer 16

Hep C and RSV

Question 17

What are Interferons used for?

Answer 17

Hep C, Hep B

Question 18

Name a cytosine analogue (NRTI).

Answer 18

Lamivudine.

Question 19

Name two purine analogues (NRTIs).

Answer 19

Abacavir.

Tenofivir.

Question 20

Which other protease inhibitor is used to boost the doses of other PIs?

Answer 20

Ritonavir.