#26 Virmani - Glomerular Disease Flashcards
Identify
Maltese CrOss
NephrOtic Syndrome
Identify
Oval Fat bodies
NephrOtic Proteinuria
Identify
Minimal Change Glomerulopathy
Thickening of basement membrane
Tx: prednisone
Identify
Focal Segmental Glomeruloscelerosis
podocyte alteration
Rapid deterioration to ESRD with collapsing variant
Identify
Collapsing FSGS
Commonly seen with HIV infection or bisphosphonates
Jones Silver stain:
The significant proliferation of podocytes to a point where it forms a pseudo crescent that obliterates the urinary space
Severe wrinkling and retraction of the GBM
Identify
Membranous GN
Nephrotic syndrome
development of immune complexes in SubEPIthelial
M-type phospholipase A2 recepter
Identify
Diabetic Nephropathy
(Nodular Glomerulosclerosis)
Identify
Membranoproliferative Glomerulonephritis (MPGN) SubENDOthelial deposits
Hematuria and proteinueria almost always present
‘tram track’
Identify and list lab results that might be seen.
Poststreptococcal GN
Group A, beta-hemolytic streptococcal
Cola-colored urine - RBCs and RBC casts
elevated ASO titer
Identify
Normal
What is the major component of the slit diaphragm in the podocyte?
Nephrin
Podocyte - highly differentiated epithlial cell
What type of collagen makes up the GBM?
Type IV
Structural support of capillary loop
What is the function of fenestrated endothelial cells?
Negatively charged and limit the passage of albumin/large molecules
When trying to distinguish the mechanism of glomerular disease which cause will target the podocytes?
Non-immune or Immune
Non-immune
Podocytopathy - fusion of the epithelial cells
Minimal change disease and FSGS
filtration barrier is compromised
What underlies most forms of primary GN and many secondary forms?
Immune mechanisms:
Antibody-mediated injury
Immune complex formation
Cytotoxic antibodies
Cell-mediatied Immune Injury
Alternative Complement Pathway