2.6 Topoisomerase inhibitors Flashcards
1
Q
What are the 5 different classes of chemotherapy?
A
- Alkylating agents
- Antimetabolites
- Topoisomerase inhbitors - Mitotic inhibitors
- Anti tumour antibiotics
2
Q
What are the 2 types of of topoisomerase inhibitors?
A
- Topoisomerase 1 inhibitors
- Topoisomerase 2 inhibitors
3
Q
Name 2 topoisomerase 1 inhibitors?
A
- Ironotecan
- Topotecan
4
Q
What is the suffix for topoisomerase 1 inhibitors?
A
Tecan
5
Q
Which phase of the cell cycle do topoisomerase inhibitors effect?
A
- S phase
- GO phase
- M phase
6
Q
What is the mode of action of topoisomerase inhibitors?
Check out the video in one note!
A
There are 2 broad classes of topoisomerases within the cell
- Topoisomerase I
- Is involved in DNA replication and transcription by forming single strand DNA breaks
- Topoisomerase II
- Is Involved in DNA replication and chromosomal segregation. Its intereaction with DNA results in double strand DNA breaks
- Topoisomerase inhibitors block the action of Topoismerase in the cancer cell leading to irreversible DNA strand breaks and cell death.
7
Q
What is a common class of topoisomerase 2 inhibitors
A
Anthracyclines
8
Q
Name 4 anthracyclines
A
- Doxorubicin
- Daunorubicin
- Apirubicin
- Adarubicin
9
Q
What is the suffix for anthracyclines
A
Rubicin
10
Q
Which phase of the cll cycle does anthracyclines effect?
A
S Phase
11
Q
Which type of cancer are anthracyclines used to treat?
A
- Solid tumours
- Haematological malignancies
