26 Clinical Use of Hormones: Focus on Steroids Mak Flashcards
How much cortisol is released in a normal person every day?
Non-stressed patients secrete cortisol amount equivalent to 5mg prednisone daily (>5mg considered supraphysiologic, may cause HPA (hypothalamus, Pituitary, Adrenal axis) suppression)
What are the steps in the HPA axis?
Hypothalamus releases CRH (corticotropin releasing hormone) which acts on the Anterior pituitary which releases ACTH (adrenocorticotropic hormone) which acts on the Adrenal cortex which releases Cortisol (which has a negative feedback function on H and P)
What are the short acting corticosteroids?
Cortisone. Hydrocortisone
What are the intermediate acting corticosteroids?
Prednisone. Prenisolone. Triamcinolone. Methyl-prednisone
What are the long acting corticosteroids?
Dexamethasone. Betamethasone
What are the Mineralcorticoids?
Fludrocortisone. Aldosterone
Which corticosteroids have the highest potency?
Long acting > intermediate > short
Which corticosteroids have the highest anti-inflammatory potency?
Long acting > intermediate > short
How often do long acting corticosteroids need to be taken?
Once a day or every other day (half-life: 36-54 hours)
How often do intermediate acting corticosteroids need to be taken?
Once a day (half-life: 12-36 hours)
What is the half-life of short acting corticosteroids?
half-life: 8-12 hours
What does Cortisol do?
Regulates metabolism of proteins, CHO, and lipids. Breakdown protein and fat. Promote gluconeogenesis (can cause glucose intolerance)
What can Cortisol deficiency cause?
Severe fatigue, weakness, weight loss, hyperpigmentation, nausea, loss of appetite
What can excess Cortisol cause?
Weight gain, fatigue, easy bruising, muscle weakness, redness in the face, pink stretch marks, mood swings
What is Cortisol products based on?
Diurnal cycle. Stress and feedback mechanism
What does Aldosterone (mineralcorticoid) do?
Sodium and water retention. Increases potassium excretion. Increases circulating blood volume (HTN, edema, exertional HA)
What does Aldosterone (mineralcorticoid) deficiency do?
Reduced blood pressure, dizziness on standing, salt craving, muscle cramps
What are oral glucocorticoids classified by?
Duration of action. Generally QD dosing except for replacement therapy (Addison’s). Longer acting agents have greater glucocorticoid activities
What will exogenous administration of glucocorticoids lead to?
Suppression of HPA axis (dose and duration related, administration time, routes, hence ADRs)
What is the dosing strategy for Glucocorticoids in chronic long-term suppression of immune response?
Daily or alternate day regimen
What is the dosing strategy for glucocorticoids to break an acute immune response?
IVP for emergency cases. Pulse therapy = high dose for a short period. Should consider tapering off
When are Glucocorticoids usually taken?
QD between 6-8am. BID for larger doses to reduce GI irritation
How can you decrease the ADRs with Glucocorticoids?
Alternate dose (e.g. 5mg prednisone one day, 2.5mg the other). Intermediate acting agents appropriate. May not minimize risk of osteoporosis or cataract formation
How can you prevent disease flare-ups with Glucocorticoids?
Tapering. Supraphysiologic doses x short duration (< 2 weeks) may be stopped without tapering. Individualize schedule. May switch to shorter acting agents when ~5mg prednisone for further tapering
What type of disease state could cause a higher risk of ADRs with Glucocorticoids?
Diseases causing lower serum albumin (e.g. Hypothyroidism)
What are some other Non-PO routes of Glucocorticoid administration?
Inhaled. Nasal. Ocular. Parenteral
How do the different Glucocorticoids compare in potency for inhaled and nasal products?
Flunisolide ~ TMC < Beclomethasone ~ Budesonide < Fluticasone ~ Mometasone
What is the PO PK of Glucocorticoids?
Completely absorbed. Peak levels in 30-100 minutes, delayed by food; bound to proteins. Hepatic metabolism and renally eliminated (Prednisone –> Prednisolone. Cortisone –> Hydrocortisone)
What is the Topical PK of Glucocorticoids?
Absorption increased by skin temperature, hydration, integrity of skin, occlusive dressing. Ointment > cream delivery. Enter systemic circulation and metabolized