25 Gastrointestinal Peptides Chan Flashcards
What are the characteristics of Gut Peptide Hormones?
Diverse cellular sources. Wide scope of biological activities. Multiple structural forms. Multiple receptor subtypes. Multiple ligand-receptor specificity. Few therapeutic applications
What is Gastrin secreted by?
G cells in the stomach
What are the effects of Gastrin?
Increases acid secretion, increases mucus growth
What is the stimulus for Gastrin release?
Peptides and amino acids in lumen; Gastrin releasing peptide and ACh in nervous reflexes
What is Cholecystokinin (CCK) secreted by?
Endocrine cells of the small intestine (Duodenum/Jejunum); neurons of the brain and gut
What are the effects of Cholescystokinin (CCK)?
Stimulates pancreatic enzyme and HCO3 secretion. Stimulates bladder contractions; inhibits stomach emptying (promotes satiety)
What is the stimulus for Cholescystokinin (CCK) release?
Fatty Acids and some Amino Acids
What is Secretin secreted by?
Endocrine cells of the small intestine (Duodenum/Jejunum)
What are the effects of Secretin?
Stimulates pancreatic and hepatic HCO3 secretion; inhibits acid secretion; Pancreatic growth. Stimulates gallbladder contraction; inhibits stomach emptying
What is the stimulus for Secretin release?
Acid in small intestine
What is Gastric Inhibitory Peptide secreted by?
Endocrine K Cells of the small intestine
What are the effects of Gastric Inhibitory Peptide?
Stimulates pancreatic insulin release. Inhibits Acid secretion. Satiety and lipid metabolism
What is the stimulus for Gastric Inhibitory Peptide release?
Glucose, Fatty Acid, and Amino Acids in small intestine
What is Motilin secreted by?
Endocrine cells in the small intestine (Duodenum/Jejunum)
What are the effects of Motilin?
Stimulates migrating motor complex for motility