2.5 Pharmaceutical Chemistry Flashcards
Drug
Substance that alters the biochemical processes in the body
Substance that alters the biochemical processes in the body
Drug
Drug use
Drugs that have beneficial effects are used in medicines
Contents of medicine
The drug plus other ingredients such as fillets to add bulk or sweeteners to improve the taste
What contains a drug plus other ingredients such as fillets to add bulk or sweeteners to improve the taste
Medicine
How do drugs work
- bind to specific proteins molecules
- proteins are found on the surface of a cell (receptor) or can be specific enzyme molecules within a cell
- bind to specific proteins molecules
- proteins are found on the surface of a cell (receptor) or can be specific enzyme molecules within a cell
How drugs work
classification of drugs that act on receptors
agonists or antagonists
what can be classified as agonists or antagonists
drugs that act on receptors
agonist
mimics the natural compound and binds to the receptor molecules to produce a response similar to the natural active compound
mimics the natural compound and binds to the receptor molecules to produce a response similar to the natural active compound
agonist
antagonist
prevents the natural compound from binding to the receptor, and so blocks the natural response from occurring
antagonist
prevents the natural compound from binding to the receptor, and so blocks the natural response from occurring
prevents the natural compound from binding to the receptor, and so blocks the natural response from occurring
antagonist
enzyme inhibitors
bind to the active site if the enzyme and blocking tue reaction normally catalysed there
bind to the active site if the enzyme and blocking tue reaction normally catalysed there
enzyme inhibitors
specificity of drug shape/size
- the overall shape and size of a drug is important to how it interacts with a receptor binding site or the active site of an enzyme. these interactions can be van der waals and/or ionic bonds
- the structural fragment of a drug molecule that allows it to form interactions with a receptor binding site or to an enzyme active site normally consist of different functional groups correctly orientated with respect to each other
comparing drugs
by comparing the structures if drugs that have similar effects in the body, the structural fragment that is involved in the drug action can be identified
