25 APR 2017 0944 MIX

Question 1

what is the MOA for dobutamine in severe cardiomyopathy / HF?

Answer 1

• stimulation of B1 receptors
• increased cAMP in cardiac myocytes
• enhanced calcium-mediated binding of actin-myosin complex to troponin C (increased contractility)
• calcium channel activation (increased HR, positive chronotrope)

Question 2

maternal HTN during pregnancy is associated with ____________________ (oligohydramnios / polyhydramnios)

Answer 2

oligohydramnios

Question 3

what are the electrolyte disturbances in tumor lysis syndrome?

Answer 3

• increased phosphorous, potassium, uric acid

- decreased calcium (phosphate binds the calcium)

Question 4

what is the preferred agent to increase appetite and weight gain in cancer-associated cachexia?

Answer 4

progesterone analogs (megestrol acetate)

Question 5

what is a hampton hump?

Answer 5

area of pulmonary infarction due to PE seen on CXR

Question 6

evidence of thrombocytopenia and microangiopathic hemolytic anemia (eg increased levels of indirect biliburin, AST, ALT, lactate dehydrogenase) should always raise suspicion for:

Answer 6

TTP

Question 7

TTP is treated emergently with:

Answer 7

plasma exchange (glucocorticoids are often added)

Question 8

what is the treatment of choice for adjustment disorder?

Answer 8

psychotherapy