25 Antidepressants and Stimulants Flashcards
Depressive disorders stem from what 2 neurotransmitters?
NE, serotonin
What are the 4 drug classes for depression?
- tricyclic antidepressants (TCA’s)
- selective serotonin reuptake inhibitors (SSRI’s)
- serotonin-norepinephrine reuptake inhibitors (SNRI’s)
- Atypical
What 4 drug classes for bipolar?
- Lithium salt
- antidepressants
- antipsychotics
- anticonvulsants
What is a common sources of drug-drug interactions among anti-depressants and bipolar treatments?
CYP activity
Type A monoamine oxidase is specific or not? Type B?
- Not
- Specific for dopamine
What drug class treats ADHD and narcolepsy? What neurotransmitters do these drugs work on?
- stimulants
- Monoamines
Which classes of antidepressants have similar efficacy within their class?
- TCA’s (tricyclics)
- SSRI’s
What receptors do TCA’s block?
- muscarinic
- adrenergic
- histamine
What reuptake systems do TCA’s block?
- serotonin
- NE
Why are SSRI’s drug of choice?
less side effects than others
MAO-A or B deaminates NE, 5-HT, & DA?
MAO-A
MAO-A or B deaminates ONLY DA?
MAO-B [considered more specific than A]
Which drug inhibits only MAO-B’s?
selegiline
MAO is located where?
inside presynaptic neuron. Acts on monoamines NE & Ser once they have undergone re-uptake
What is cheese effect?
Pt. is taking a MAOi. Tyramine in cheese doesn’t get degraded by MAO. Get headache, tachycardia, hypertension, seizures, stroke. [Rather than oral, Use transdermal selegiline to avoid this]
