2.5

Question 0

Cystic fibrosis occurs because people with CF have a faulty version of a protein called CFTR that transports

Answer 0

Chloride ions across cell membranes

Question 1

Cystic fibrosis is an inherited disorder that affects

Answer 1

Plasma membranes

Question 2

CFTR is coded for by a gene on

Answer 2

Chromosome 7

Question 3

A gene is a

Answer 3

Length of DNA that occupies a specific position on a chromosome

Question 4

A locus is a

Answer 4

Specific position on a chromosome

Question 5

Each gene codes for a

Answer 5

Specific protein or polypeptide

Question 6

A particular gene may have more than one form that is slightly different from the others in its sequence of nucleotide bases - these different forms of genes are called

Answer 6

Alleles

Question 7

The allele that codes for cystic fibrosis has

Answer 7

3 nucleotides missing

Question 8

The three missing nucleotides code for one amino acid, so this means that the faulty CFTR protein has one

Answer 8

Amino acid missing

Question 9

(CF) this missing amino acid is very significant. Without it the CFTR protein folds up into a different tertiary structure, resulting in a protein that will

Answer 9

Not function

Question 10

Human DNA is arranged in the form of

Answer 10

Chromosomes

Question 11

Human body cell contains 23 pairs of chromosomes, making

Answer 11

46 in all

Question 12

A gamete contains one set of 23 chromosomes. This means that every individual receives one set of chromosomes from

Answer 12

Their mother and one from their father

Question 13

Every individual has two genes that code for CFTR, however, the two
Alleles may be the

Answer 13

Same or different

Question 14

If an individual has 2 identical alleles of a gene, they are said to be:

Answer 14

Homozygous for that gene

Question 15

If the alleles are different, they are said to be

Answer 15

Heterozygous

Question 16

An allele is said to be dominant if it is always expressed in the

Answer 16

Phenotype

Question 17

Phenotype =

Answer 17

The characteristics of an organism resulting from its alleles

Question 18

The allele for the normal CFTR protein can be identified with the symbol:

Answer 18

F

Question 19

Allele for normal CFTR protein is

Answer 19

Dominant

Question 20

The allele for the faulty version of CFTR is

Answer 20

Recessive

Question 21

Faulty CFTR allele can be identified with symbols

Answer 21

f

Question 22

Faulty CFTR allele means that it is only expressed in the phenotype of an individual if

Answer 22

Two copies of the allele are present

Question 23

The genotype of an individual is their

Answer 23

Genetic make up

Question 24

The genotype tells you the

Answer 24

Alleles they carry

Question 25

A person with the genotype Ff is

Answer 25

Heterozygous for the cystic fibrosis gene

Question 26

A person who is FF or ff is

Answer 26

Homozygous

Question 27

Heterozygous = do not have CF because the normal allele is

Answer 27

Dominant

Question 28

2 people who are heterozygous for the CFTR gene may have child with CF this is because a person who is heterozygous passes on only one of their alleles into each gamete. If the child inherits one faulty CFTR allele from each parent then they will develop

Answer 28

CF

Question 29

Sometimes we say that heterozygous individuals who will not have CF but could pass on CF to their own children are

Answer 29

Carriers of cystic fibrosis

Question 30

Monohybrid inheritance involves a cross between individuals in which only a

Answer 30

Single gene is being considered

Question 31

Cystic fibrosis is an example of a

Answer 31

Monohybrid cross