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Question 1

Neuropath findings in Alzheimer’s:

Answer 1

loss of cerebral cortical neurons

neuritic plaques with bet-amyloid

neurofibrillary tangles

Question 2

Genes linked to early onset Alz:

Answer 2

APP (AD1) on chromosome 21

Presenilin 1 (AD3) on chr 14

Presenilin 2 (AD4) on chr 1

Question 3

Gene linked to later onset or sporadic Alz:

Answer 3

ApoE4 (AD2) on chr 19

Question 4

Symptomatic trx for Alz?

Answer 4

AChE –> increased ACh-related neuronal activity in neocortex

Question 5

Appearance of Lewy bodies?

Answer 5

eosinophilic, spherical inclusions with halo appearance

Question 6

Where are Lewy bodies found?

Answer 6

cytoplasm of neurons in sub. nigra

Question 7

Lewy bodies are comprised of:

Answer 7

neurofilament proteins, alpha-synuclein, ubiquitin

Question 8

Pathology of frontotemporal dementias?

Answer 8

atrophy of frontal and temporal lobes

Question 9

Hallmark of FTDs?

Answer 9

neurofibrillary tangles, +/- Pick bodies (comprised of ubiquitin and hyperP tau protein)

Question 10

Mutation associated with Pick’s?

Answer 10

tau protein, chr 17