24-HPV Flashcards
What are the risk factors for HPV infection?
Sexual activity
Multiple partners
Younger age at sexual debut
Lack of condom use
What are the risk factors for persistent HPV infection and/or neoplastic progression?
Smoking HPV type Increasing age Lack of condom use Immunodeficiency (HIV) Oral contraceptive STI
What is the goal of cervical cancer screening?
Identify and treat high grade cervical cancer precursors
Reduce a woman’s risk of developing invasive cervical cancer
Prevent unnecessary and potentially hazardous evaluations and treatment
Minimize costs to healthcare system
What are the requirements of cervical cancer prevention?
Screening
Evaluation of screen positive women using colposcopy and cervical biopsy
Treatment of women with biopsy confirmed high grade cervical precursors
What are the 2 types of cell abnormalities?
Squamous cell abnormalities
Glandular cell abnormalities
What is the clinical significance of atypical squamous cell or undetermined significance( ASC-US)?
Most common cytology abnormality
Prevalence of CIN is 7-12%
What is the clinical significance of ASC-H?
Uncommon cytology abnormality
Much higher risk of CIN than in ASC-US
What is the clinical significance of LSIL?
Common cytology abnormality
Found more commonly in liquid based cytology specimens
Good indicator of HPV infection
What is the clinical significance of HSIL?
Relatively uncommon cytology abnormality
Rate varies with age
What is the clinical significance of AGC?
Relatively uncommon cytology
More common in women 40 years and older
