24 General Therapy Overview Flashcards
What chemotherapy is used to treat SCLC?
EP + RT (Etoposide + Cisplatin + Radiation therapy)
What is treatment of choice for NSCLC Stage I, II, IIIa?
Surgery w/ curative intent
What chemotherapy is used for NSCLC Stage II, IIIa?
ADJUVANT Cisplatin-based
What is first line treatment for NCSLC Stage IIIb, IV, metastatic?
Carboplatin-Paclitaxel + Bevacizumab
What is used in lung cancer for EGFR (+)?
Erlotinib
What is used in lung cancer for ALK (+)?
Crizotinib
What is the first line hormonal therapy for Prostate Cancer?
GnRH agonist (Leuprolide, Goserelin) +/- Anti-androgen (CAB)
What are the anti-androgens used in prostate cancer?
Bicalutamide (Casodex), Flutamide (Eulexin), Nilutamide (Nilandron)
What is the first line chemotherapy for metastatic Prostate Cancer?
Docetaxel + Prednisone
What is the most common adjuvant chemotherapy for breast cancer?
AC –> Paclitaxel (T). Anthracycline (Doxorubicin) + Cyclophosphamide x4 cycles (3 weeks each) –> Paclitaxel IV weekly x12 weeks +/- Traztuzumab (Her2) IV weekly x1 year
What adjuvant chemotherapy can be used for breast cancer in a patient with nodal involvement and possible underlying cardio issues?
TC +/- H. Docetaxel + Carboplatin x6 cycles (3 weeks each) +/- Trastuzumab x1 year
What adjuvant therapy is used for Her2 (+) breast cancer?
Traztuzumab (Herceptin) or Pertuzumab (Perjeta)
What is the most common first line adjuvant therapy for ER (+) breast cancer?
Tamoxifen (Saltamox) - most common anti-estrogen used
What is the NCCN recommended therapy for resected Adjuvant Stage II Colon cancer?
5-FU/Leucovorin
What is the NCCN recommended therapy for resected Adjuvant Stage III Colon cancer?
FOLFOX (repeat Q2 weeks) for 6 months
What is in FOLFOX?
Oxaliplatin, 5-FU/Leucovorin
What is the NCCN recommended therapy for advanced metastatic colon cancer?
FOLFOX + Bevacizumab
What are the first line agents for renal cell cancer?
TKIs: Sorafenib (Nexavar), Sunitinib (Sutent). Temsirolimus (Torisel). IL-2 (Proleukin)
What is the standard therapy for Acute Myelogenous Leukemia (AML) Induction (< 60 yo)?
Combination of Cytarabine + Anthracycline (1-2 cycles). “7+3”: Cytarabine on days 1-7, and Idarubicin or Daunorubicin on days 1-3
What is the only curative therapy for Chronic Myelogenous Leukemia (CML)?
Allogeneic stem cell transplant
What is 1st line treatment for CML?
TKIs: Dasatinib, Nolitnib > Imatinib
What is the main agent used for Multiple Myeloma?
Thalidomide (Thalomid). Bortezomib (Velcade) is also a first line choice
Treatment option for aggressive Non-Hodgkin’s Lymphoma (NHL)?
R-CHOP, repeat every 21 days
What is R-CHOP?
Rituximab (Rituxan). Cyclophosphamide (Cytoxan). Hydroxyl Daunorubicin. Vincristine (Oncovin). Prednisone
