24 General Therapy Overview

Question 1

What chemotherapy is used to treat SCLC?

Answer 1

EP + RT (Etoposide + Cisplatin + Radiation therapy)

Question 2

What is treatment of choice for NSCLC Stage I, II, IIIa?

Answer 2

Surgery w/ curative intent

Question 3

What chemotherapy is used for NSCLC Stage II, IIIa?

Answer 3

ADJUVANT Cisplatin-based

Question 4

What is first line treatment for NCSLC Stage IIIb, IV, metastatic?

Answer 4

Carboplatin-Paclitaxel + Bevacizumab

Question 5

What is used in lung cancer for EGFR (+)?

Answer 5

Erlotinib

Question 6

What is used in lung cancer for ALK (+)?

Answer 6

Crizotinib

Question 7

What is the first line hormonal therapy for Prostate Cancer?

Answer 7

GnRH agonist (Leuprolide, Goserelin) +/- Anti-androgen (CAB)

Question 8

What are the anti-androgens used in prostate cancer?

Answer 8

Bicalutamide (Casodex), Flutamide (Eulexin), Nilutamide (Nilandron)

Question 9

What is the first line chemotherapy for metastatic Prostate Cancer?

Answer 9

Docetaxel + Prednisone

Question 10

What is the most common adjuvant chemotherapy for breast cancer?

Answer 10

AC –> Paclitaxel (T). Anthracycline (Doxorubicin) + Cyclophosphamide x4 cycles (3 weeks each) –> Paclitaxel IV weekly x12 weeks +/- Traztuzumab (Her2) IV weekly x1 year

Question 11

What adjuvant chemotherapy can be used for breast cancer in a patient with nodal involvement and possible underlying cardio issues?

Answer 11

TC +/- H. Docetaxel + Carboplatin x6 cycles (3 weeks each) +/- Trastuzumab x1 year

Question 12

What adjuvant therapy is used for Her2 (+) breast cancer?

Answer 12

Traztuzumab (Herceptin) or Pertuzumab (Perjeta)

Question 13

What is the most common first line adjuvant therapy for ER (+) breast cancer?

Answer 13

Tamoxifen (Saltamox) - most common anti-estrogen used

Question 14

What is the NCCN recommended therapy for resected Adjuvant Stage II Colon cancer?

Answer 14

5-FU/Leucovorin

Question 15

What is the NCCN recommended therapy for resected Adjuvant Stage III Colon cancer?

Answer 15

FOLFOX (repeat Q2 weeks) for 6 months

Question 16

What is in FOLFOX?

Answer 16

Oxaliplatin, 5-FU/Leucovorin

Question 17

What is the NCCN recommended therapy for advanced metastatic colon cancer?

Answer 17

FOLFOX + Bevacizumab

Question 18

What are the first line agents for renal cell cancer?

Answer 18

TKIs: Sorafenib (Nexavar), Sunitinib (Sutent). Temsirolimus (Torisel). IL-2 (Proleukin)

Question 19

What is the standard therapy for Acute Myelogenous Leukemia (AML) Induction (< 60 yo)?

Answer 19

Combination of Cytarabine + Anthracycline (1-2 cycles). “7+3”: Cytarabine on days 1-7, and Idarubicin or Daunorubicin on days 1-3

Question 20

What is the only curative therapy for Chronic Myelogenous Leukemia (CML)?

Answer 20

Allogeneic stem cell transplant

Question 21

What is 1st line treatment for CML?

Answer 21

TKIs: Dasatinib, Nolitnib > Imatinib

Question 22

What is the main agent used for Multiple Myeloma?

Answer 22

Thalidomide (Thalomid). Bortezomib (Velcade) is also a first line choice

Question 23

Treatment option for aggressive Non-Hodgkin’s Lymphoma (NHL)?

Answer 23

R-CHOP, repeat every 21 days

Question 24

What is R-CHOP?

Answer 24

Rituximab (Rituxan). Cyclophosphamide (Cytoxan). Hydroxyl Daunorubicin. Vincristine (Oncovin). Prednisone

Question 25

What is the gold standard for HD treatment?

Answer 25

ABVD: Days 1 and 15 every 28 days for 6-8 cycles

Question 26

What is ABVD?

Answer 26

Doxorubicin (Adriamycin). Bleomycin (Blenoxane). Vinblastine (Velban). Decarbazine (DTIC)