24. Biliary/Liver 2 Flashcards

1
Q

Signs of pancreatic cancer?

A

Painless jaundice and a palpable gallbladder - 75% in head of pancreas from exocrine tissue

Rest are MEN1 arising from endocrine tissue

FLAWS
Exocrine - steatorrhoea
Endocrine - diabetes
Hepatomegaly
Trossaeu sign (migratory thrombophelbitis)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Investigations for pancreatic cancer?

A

Bloods - CA19-9
USS
High res CT if number 1 differential - see double duct sign
Gold standard is biopsy by ERCP or US

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Management of pancreatic cancer?

A

ERCP for stenting

Whipple’s resection with adjuvant chemo – side effect would be dumping syndrome (rapid gastric emptying) or PUD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is a cholangiocarcinoma?

A

Cancer arising from bile ducts either intrahepatic or extrahepatic.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Signs and symptoms of a cholangiocarcinoma?

A
Virchow's node
Sister mary joseph nodule
FLAWS
RUQ pain 
Bile obstruction - jaundice, palpable GB, pruritus, pale stool and dark urine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Investigations for cholangiocarcinoma?

A

Bloods - LFTs (obstructive), clotting, CA19-9 and CEA
Imaging - USS and MRCP
Radiography - PTC
ERCP with biopsy is gold standard

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Management for cholangiocarcinoma?

A
Depends on where cancer is 
- Removal of bile duct 
- Partial hepatectomy 
- Whipple's proceduce (distal BD tumours)
Adjuvant chemo or radiotherapy
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is a hepatocellular carcinoma?

A

Primary malignancy of hepatocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Signs and symptoms of HCC?

A
Presents late (like rest)
FLAWS
Chronic liver failure symp -
Hepatosplenomegaly
Pruritus
Jaundice
Decompensation -
Acute deterioration of liver failure
Hepatic encephalopathy
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

How to investigate HCC?

A

Screening for RFs e.g. haemochromatosis, alc hep etc.
Bloods - aFP tumour marker
Imaging - USS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How to manage HCC?

A
Early
- Surgical resection (non-cirrhotic)
- Transplant (cirrhotic)
Unsuitable 
- Percutaneous ethanol injections
- Multikinase inhibitor with sorafenib
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is primary biliary cirrhosis?

A

Autoimmune condition associated with granuloma formation in the bile ducts. Inflammatory disorder causing destruction of interlobular bile ducts.

More common in women.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Signs and symptoms of PBC?

A
Pruiritus and jaundice (obstruction)
RUQ pain
Xanthelasma and xanthomata
Clubbing
Hepatosplenomegaly
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Investigations for PBC?

A

Bloods - AMA M2 antibodies (raised serum IgM too)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

How to treat PBC?

A

Treat symptoms

Vitamin A, D, E and K supplements
Ursodeoxycholic acid
Cholestyramine for pruritis
Transplant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is primary sclerosing cholangitis?

A

Biliary inflammation of unknown aetilogy, inflammation of intra or extrahepatic ducts

17
Q

Signs and symptoms of PSC?

A

Pruritus, jaundice, fatigue, RUQ pain

18
Q

Investigations for PSC?

A

Bloods - pANCA positive
ERCP/MRCP - bead on a string appearance
Biopsy - onion skin fibrosis

19
Q

How to manage PSC?

A

Screen for cholangiorcinoma
Follow up LFTs and tumour markers every 6 months
Proceed to ERCP and biopsies of any suspicious lesions

20
Q

What is wilson’s disorder?

A

An autosomal recessive disorder where there is excessive copper deposition in tissues.
Increased copper absorption from SI and decreased hepatic excretion.

21
Q

Signs and symptoms of wilson’s?

A

Neuro - parkinsonism, behavioural changes, psychiatric or speech distubances
Eyes - kayser-fleischer rings
Liver - hepatitis and cirrhosis

22
Q

Investigations wilson’s

A

Slit lamp eye examination
Bloods LFTs, reduced serum caeruloplasmin and raised free copper
Urinalysis - increased 24hr copper excretion
Genetic testing/liver biopsy

23
Q

How to manage wilson’s?

A

Copper chelation with penicillamine

Other chelation - trientine hydrochloride, tertrathiomolybdate

24
Q

What is haemochromatosis?

A

Abnormal iron deposition in certain organs causing oxidative damage
Primary - due to mutation on HFE gene, autosomal recessive
Secondary to frequent blood transfusions, iron supplementation or diseases of erythropoiesis

25
Q

Signs and symptoms of haemochromatosis?

A

Liver, pancreas, skin, pituitary, heart and joint affected.

Classic triad - cirrhosis, diabetes, bronze pigmentation

Lethargy
Impotence
Arthralgia
Deranged LFTs

26
Q

Investigations for haemochromatosis?

A
Serum ferritin raised
Transferring >45%
LFTs raised AST and ALT
FBC normal
Genetic testing
Liver biopsy 
Investigate through presenting complaint
27
Q

How to manage haemochromatosis?

A

Guided by - serum transferrin, ferritin, clinical symptoms
Avoid iron and vit c supplements and alcohol intake
Stage 0 - monitor every 3 years
1 - monitor every year
2-4 - venesection/iron chelation therapy
End stage - liver transplant