2. Blood Cancers and Disorders Flashcards
What are our three types of blood cancers?
Leukaemia
Lymphoma (arising from lymphatic cells)
Others
How is leukaemia divided?
Myeloid (red cells)
Lymphoid (T and B cells)
How are lymphomas divided?
Hodgkin
Non-hodgkin
What is leukaemia?
Blood cancers that begin in bone marrow and result in high numbers of abnormal blood cells – dysfunctional cells crowd out bone marrow to prevent formation of other important blood cells
What’s the difference between acute and chronic leukaemia?
Acute - rapid increase in immature cells, abnormal differentiation and excessive proliferation cause severe leukaemia
Chronic - excessive build up of relatively mature white blood cells, normal differentiation and excessive proliferation (more common in older)
What are features of acute myeloid leukaemia (AML)?
Bone marrow failure (neutropenia, aneamia, thrombocytopenia) - pallor, bleeding, infections
Tissue infiltration - swollen gums, mild splenomegaly
Auer rods on cytology, rods in blood cells
What is acute promyelocytic leukaemia?
Hyper-aggressive subtype of AML, faggot cells on cytology - lots of auer rods
Features of acute lymphoblastic leukaemia?
Bone marrow failure - pallor, bleeding, infections
Tissue infiltration - lymphadenopathy, hepatosplenomegaly, swollen testes, tender bones
> 20% lymphoblasts on marrow biopsy
Often after influenza, common in children
Features of chronic myeloid leukaemia?
Caused by philadelphia chromosome, most are asymptomatic
90% have splenomegaly - key features!!
Hyperproliferation of granulocyte precursors (more mature cells than AML) -
Hypermetabolic symptoms - weight loss, malaise, sweating
Bone marrow failure - same as rest
Hyperviscosity - thrombotic events, headaches
What are the phases of CML?
Chronic phase
Accelerated phase
Blast crisis - similar to an acute leukaemia
Features of chronic lymphocytic leukaemia?
Progressive accumulation of functionally incompetent lymphocytes.
Mostly asymptomatic but sometimes lymphadenopathy or bone marrow failure symptoms
Smear/smudge cells on blood film
Leukaemia investigations
Bloods - smear, LDH, FBC
Biopsy - bone marrow aspirate
Other - CXR, immunophenotyping
Treatment of leukaemia?
Chemotherapy first line
Bone marrow transplants
Palliative care
What is a lymphoma?
A group of cancer developing from lymphocytes, mainly found in lymph nodes
How do patients with a lymphoma present?
A lump and systemic/B symptoms - fever, weight loss, night sweats.