23. Immunizations Flashcards
Vanessa is pregnant with her second child. She is in the second trimester. Vanessa is not sure what childhood vaccines she received and is positive she has not been vaccinated for anything in at least fifteen years, since that is when she left her parents home and lost her medical insurance. Which vaccine is recommended for Vanessa during her pregnancy? (SelectALL that apply.)
A. Influenza shot, at any time of the year
B. Tdap
C. Measles, mumps and rubella
D. Shingles
E. Influenza shot, if during flu vaccination season
B, E. The influenza vaccine is recommended during any stage of pregnancy. FluMist is a live vaccine; live vaccines are not used during pregnancy. If rubella vaccine (in MMR) was administered during pregnancy the baby would suffer severe birth defects.
A 12-month old child was hospitalized two months ago and received immuneglobulin. Which vaccine/s would be adversely affected by this treatment if administered today? (Select ALL that apply.)
A. Pneumococcal conjugate vaccine
B. Inactivated polio vaccine
C. Measles, mumps, rubella vaccine
D. Influenza vaccine, inactivated
E. Varicella vaccine
C, E. Live vaccines are affected by immuneglobulins.
Select the signs and symptoms of tetanus: (Select ALL that apply.)
A. Muscle rigidity
B. Painful muscle spasms
C. Hypotension
D. Bradycardia
E. High fever
A, B, E. Tetanus (lockjaw) is a serious disease that causes painful tightening of the muscles, usually all over the body. It can lead to “locking” of the jaw so the victim cannot open his mouth or swallow. Tetanus leads to death in about 1 in 10 cases.
Each of the following groups should receive hepatitis B vaccine except:
A. Unvaccinated adults with ESRD
B. Unvaccinated adults with asthma
C. Sexually-active adults who are not in a long-term, monogamous relationship (1 partner)
D. All infants, beginning at birth
E. Healthcare workers who work in hospitals
B.
A 70 year old female enters the pharmacy and requests a vaccination against shingles (herpes zoster). Prior to administering the vaccine the following screening question must be asked:
A. Have you ever had a life-threatening allergic reaction to the antibiotic streptomycin?
B. Do you have a history of smoking?
C. Are you taking medication for thyroid disease?
D. Are you receiving more than 5 mg prednisone per day for at least the past two months?
E. Have you ever had a bad reaction to gelatin?
E. Shingles is a live vaccine and cannot be administered to severely immuno-compromised patients. Both shingles and chickenpox cannot be administered to anyone with a true allergy to neomycin or to gelatin (components of the vaccine). The steroid dose indicated here is not enough to cause immune-suppression. Review the steroid doses in the text that would be considered a contraindication to live vaccines.
Evangelos is a 50 year-old male who approaches the counter to ask for the best option to treat a cut he received on his foot while working in his garden. Evangelos does not believe he received many childhood vaccines. Which vaccine is preferable?
A. DTaP
B. DT
C. Td
D. Tdap
E. Menveo
D. A person who gets a cut or burn might need a dose of Td or Tdap to prevent tetanus infection. Tdap should be used for anyone who has never had a dose previously. Td should be used if Tdap is not available, or for anybody who has already had a dose of Tdap, and for adults 65 and older.
The manager at Huntington Pharmacy has ordered 100 single-dose vials of Fluvirin. He found them in the store’s freezer. Choose the correct course of action:
A. The vaccine can be moved into the refrigerator if it has been frozen less than 1 hour.
B. The vaccine cannot be used; it must be safely discarded.
C. The vaccine can be used if administered within 24 hours.
D. The vaccine can be used if administered within 48 hours.
E. The vaccine can be used if administered within 72 hours.
B. Vaccine that requires refrigeration cannot be stored in the freezer. If it has been frozen in error, the vaccine has been wasted.
Occasionally a patient receives a vaccine that is not administered in the proper location. Which of the following statements concerning intramuscular injection in an adult is incorrect?
A. Inject into the central and thickest portion of the deltoid muscle.
B. The injection site is above the level of the armpit and below the acromium.
C. Separate two injections in the deltoid by a minimum of one inch.
D. Td, Tdap, Hepatitis A, Hepatitis B, HPV, trivalent inactivated influenza, and meningococcal MCV4 are given by IM injection. Polio, IPV, and Pneumovax can be given SC or IM.
E. Always inject into the same arm to ensure consistent absorption.
E.
A pharmacist is preparing an injection for a male patient, 63 years old, who weighs 280 pounds. The pharmacist is going to administer the Zostavax vaccine. Which of the following statements concerning Zostavax injection is correct? (Select ALLthat apply.)
A. Use a needle at least 1.5” long.
B. The vaccine must be reconstituted prior to use with sterile or bacteriostatic water.
C. Zostavax will help protect the patient against a herpes zoster outbreak.
D. The patient is not old enough to receive this vaccine.
E. This vaccine is administered subcutaneously in the fatty tissue over the triceps.
C, E. This injection is given subcutaneously with a needle that is 5/8” long. Pinch up on the tissue to prevent injecting into muscle, although this is more of an issue with thin patients than the patient described in this question. The vaccine must be reconstituted prior to use with the supplied diluent. Zostavax will help protect the patient against a herpes zoster outbreak, which is shingles.
Select the correct statement concerning pneumococcal vaccination in patients 65 and older:
A. They should receive Pneumovax 23 unless received within the past 5 years.
B. They should receive Prevnar 13 unless received within the past 5 years.
C. They should receive Prevnar 13 x 1, followed by Pneumovax 23 five years later.
D. They should receive Prevnar 13 (if not given previously) followed by Pneumovax 23 6 to 12 months later by a dose of Pneumovax 23.
E. They should receive Pneumovax 23 x 1, followed by Prevnar 13 five years later.
D. Ages 65 and older require Prevnar 13 (if not given previously) followed by Pneumovax 23 6 - 12 months later by a dose ofPneumovax 23. If Pneumovax 23 was given first, wait at least 1 year before giving Prevnar 13.
Select the correct name for the chickenpox vaccine:
A. Zovirax
B. Varivax
C. Valtrex
D. Zostavax
E. Engerix-B
B. Look-alike drug names contribute to the most common error pharmacists make, which is dispensing the wrong medication.
The shingles vaccine is used to prevent shingles outbreak. Children receive the chickenpox vaccine. Which of the following statements are correct? (Select ALL that apply.)
A. Varivax vaccine is given to persons ages 60 years and older.
B. If a patient has an outbreak and suffers pain, they can use lidocaine orally for pain relief.
C. To prevent varicella (chickenpox) in children they can receive a combination vaccine for MMR and varicella (MMRV) called ProQuad.
D. Another name for shingles is herpes simplex.
E. Varicella vaccines are live vaccines.
C, E. Shingles can cause severe nerve pain. The lidocaine patch (Lidoderm) is approved to treat the pain, and other agents are as well, but the pain can remain significant in 5-10% of patients with shingles. Lidocaine viscous gel is used topically for pain relief. Another name for shingles is herpes zoster. Another name for the resultant chronic pain that may occur post-shingles outbreak is herpetic neuralgia.
Which of the following statements concerning the recombinant vaccine FluBlok are correct? (Select ALL that apply.)
A. If a patient wishes to receive FluBlok and they have had a severe reaction to eggs (anaphylaxis) they cannot receive FluBlok in the pharmacy.
B. FluBlok is produced with recombinant DNA techniques and is completely free of egg products.
C. FluBlok is given subcutaneously.
D. FluBlok is preferred in children E. Flublok can be administered to patients 18 years and older.
B, E. If a patient wishes to receive FluBlok and they have had a severe reaction to eggs (anaphylaxis) they can certainly receiveFluBlok in the pharmacy; FluBlok is a recombinant vaccine and is not produced in hen embryos. FluBlok is 100% egg-free. Children 6 months to 8 years should be receiving FluMist, the quadrivalent nasal spray, per the CDC.
Which of the following statements concerning an intramuscular (IM) injection are correct? (Select ALL that apply.)
A. Separate two IM injections by at least one inch.
B. Meningococcal (MCV) is given by IM injection.
C. Varivax is SC only; Zostavax is IM or SC.
D. Inactivated polio vaccine is either SC or IM.
E. Pneumovax is SC only.
A, B, D. Pneumococcal polysaccharide (Pneumovax) and the inactivated polio vaccine (IPV) are either SC or IM; no preference is stated by ACIP.
Epinephrine injection now comes in a “talking” injection device that can help guide patients how to administer the injection. What is the name of this device?
A. Evzio
B. Copaxone
C. Lemtrada
D. Arixtra
E. Auvi-Q
E. Auvi-Q is a newer device that is easy to use; however, the EpiPen is also simple to use.
Evzio (naloxone auto-injector) for opioid overdose
Copaxone (glatiramer acetate) for multiple sclerosis
Lemtrada (alemtuzumab) treats leukemia
Arixtra (fondaparinux) prevents blood clots, factor Xa inhibitor
Pharmacists have sometimes dispensed the wrong hepatitis vaccines. It is helpful to know some of the names in order to make sure the correct vaccine is chosen. Vaccines can be kept in labeled bins in the refrigerator with warnings for agents that are likely to be involved in mix-ups. Which vaccine contains combined Hepatitis A and B vaccines?
A. Engerix-B
B. Recombivax-B
C. Comvax
D. Pediarix
E. Twinrix
E. The name Twinrix is a clue (“twin’) that two vaccines are included.
Benjamin is a 54 year-old male who enters the pharmacy to get his annual flu shot, but he is coughing and sneezing. He has a cold and says his cough kept him up all night. Select the correct statement:
A. He should get the flu shot today.
B. He should wait until the illness symptoms have cleared.
C. He should wait at least a month before he challenges himself with a flu vaccine.
D. He should get FluMist; it is better to avoid a painful shot when you are ill.
E. He should get the intradermal flu shot which causes less swelling than the IM injection.
A. Mild illness is not a contraindication to vaccination.
Many types of medications are self-administered by patients. These require careful instruction by the pharmacists on how to safely store and administer the injection devices or syringes, and how to dispose of the used material. Which of the following statements is correct?
A. The skin where the patient injects is rubbed after an EpiPen injection but is not rubbed after an enoxaparin injetion.
B. The EpiPen is only for use by a trained healthcare professional.
C. The EpiPen can only be self-administered once for each episode.
D. The EpiPen is administered in the abdomen.
E. The EpiPen is kept refrigerated prior to use.
A. Both enoxaparin (Lovenox) and the EpiPen are stored at room temperature. Many self-injectables require refrigeration. It is important to rub the skin after using an EpiPen to help the medication reach the lungs quickly. Do not rub after injecting an anticoagulant; bruising/bleeding could occur in that location.
Which of the following is true regarding herpes zoster vaccine? (Select ALL that apply.)
A. Store the unused vaccine vials (powder) in the refrigerator.
B. Store the unused vaccine vials (powder) at -15 degrees Centigrade.
C. Once reconstituted the vaccine must be used within 30 minutes or discarded, according to ACIP.
D. The diluent must be stored in the refrigerator only.
E. The vaccine is administered SC with a 5/8” needle.
B, C, E.
Which of the following groups ages 19-64 years should receive Prevnar followed by Pneumovax at least 8 weeks later and then again 5 years after the first Pneumovax dose? (Select ALL that apply.)
A. A patient with HIV infection.
B. A patient with chronic renal failure.
C. A solid organ transplant recipient.
D. A patient with lymphoma receiving treatment.
E. A patient with multiple myeloma receiving treatment.
A, B, C, D, E. These patients are immunocompromised and should receive this regimen.
A 12 month old child was hospitalized two months ago and received immuneglobulin. Which vaccine would be adversely affected by this treatment?
A. Pneumococcal conjugate
B. Polio vaccine
C. Measles
D. Influenza vaccine, shot, inactivated
E. Hepatitis B vaccine
C. Immunoglobulin administration must be separated from live vaccines, including measles and varicella, for at least three months.
A child was not vaccinated for meningococcal disease. The child is at risk for severe disease and complications, including death. Which of the following is true regarding meningococcal disease/vaccine? (Select ALL that apply.)
A. MCV is given IM, MPSV is given SC.
B. Patients who are 2 months-55 years old who are considered high disease risk and should be vaccinated include those living in college dormitories.
C. Patients who are 2 months-55 years old who are considered high disease risk and should be vaccinated include those in the military.
D. Some patients will require repeat vaccination.
E. Meningitis is no longer a routine childhood vaccination.
A, B, C, D. Anyone can get meningitis but it is most common in infants less than one year of age and in people ages 16-21 years. Up to age 55 MCV4 (the conjugate version) is preferred. After age 55 only the polysaccharide version is licensed for use (MPSV4). The redness and pain at the injection site affects about half the patients being vaccinated and dissipates in 1-2 days.
Which of the following, if taken, would qualify as a steroid-induced immune suppressive state? (Select ALL that apply.)
A. The use of a beclomethasone inhaler twice daily for at least 4 weeks.
B. A patient who was recently infected with HIV.
C. An adult who received 4 mg of dexamethasone daily for the past three weeks.
D. An 11.8 kg child receiving 30 mg of prednisolone for the past 22 days.
E. An elderly female who received a triamcinolone intra-articular injection for gout x 1 two days ago.
C, D. Steroid-induced immunesuppression is given in terms of prednisone equivalent doses on page 316 of the Immunization chapter in the 2015 RxPrep course book. The equivalent steroid doses to prednisone are in the asthma chapter of the RxPrep course book.
Inhalers, and injections into the joints do not count as steroid-induced immune suppression.
Which of the following represent patient groups that are candidates for the shingles vaccine, according to the ACIP recommendations?
A. Adults 50 years and older
B. Adults 60 years and older
C. Adults 50 years and older and children at 2-3 months and 10-11 years
D. Adults 60 years and older and children at 2-3 months and 10-11 years
E. Adults 60 years and older and college students who live in dormitories
B. The herpes zoster (shingles) vaccine is live and cannot be given to patients with severe immunosuppression. This includes individuals with AIDS or clinical manifestations of HIV, such as a CD4+ count less than 200 per mm3 and patients on high doses of steroids (prednisone or its equivalent of 20 mg daily or more for more than 2 weeks). It does not matter if the person had chickenpox as a youngster; they can still get shingles and are vaccinated. The FDA has approved the shingles vaccine for adults over 50 years of age, but this is not the current recommendation from ACIP. It may change to match the approval; if this occurs then the protocols used in community pharmacies will need to be amended. There is uncertainty at present over when adults will need a booster–if they get vaccinated at a younger age, then the protection wanes when older. Until this is figured out the ACIP may leave the recommendation at 60.
A pharmacist is working in a hospital that requires hepatitis B vaccination. She received her 1st dose of a 3-dose series. She did not return for the 2nd dose, which was due one month later. It is now four months after the 1st dose. Select the correct recommendation:
A. She is more than 30 days late with the 2nd dose; she must start the series over.
B. She is more than 60 days late with the 2nd dose; she must start the series over.
C. She is more than 90 days late with the 2nd dose; she must start the series over.
D. She is no longer a candidate for hepatitis B vaccination.
E. She should get the 2nd dose now and return for the 3rd dose at the proper time.
E. Hepatitis B infection is the major infectious hazard for health-care personnel. Persons with chronic infection are at risk for chronic active hepatitis, cirrhosis, and primary liver cancer. There are different vaccines available, but the usual schedule is three doses, given by IM injection: 1st dose followed by a 2nd dose one month later and a 3rd dose six months after the 1st dose. It is acceptable to catch-up on doses if late (give them when the patient comes in), but recommended dosing schedules cannot be sped-up. It is best not to miss vaccines; the delay increases the risk of infection.
Hendrick is a community pharmacist who runs a vaccination clinic. He wants to review current vaccine administration recommendations. What source is best for Hendrick to obtain the current vaccine recommendations and other essential immunization information?
A. Centers for Disease Control (CDC) website
B. Koda Kimble: Applied Therapeutics
C. His old pharmacy school notes
D. The vaccine manufacturer’s product package inserts
E. A website he found by searching with Google
A. The CDC website contains the vaccination schedules and much useful information. The vaccine updates are generated by the Advisory Committee on Immunization Practices (ACIP) and published in the Morbidity and Mortality Weekly Report (MMWR). All of this information is available from the CDC website. The Pink Book is on the CDC website, in both chapters for free download and some of the topics in slide-sets. The Pink Book (which used to be ordered and was pink–prior to the use of the internet) covers all aspects of immunization, including a background on immunology and principles of immunization.
Select the correct statement concerning the hepatitis B virus:
A. Hepatitis B is a deadly form of the hepatitis virus, yet there is no vaccine available.
B. Hepatitis B is transmitted by ingestion of fecal matter from contaminated foods and drinks.
C. Hepatitis B is transmitted by contact with infected body fluids (sex, IV drug abuse, mother to child, needlestick injury).
D. Pharmacists who work in a hospital and have exposure to needlesticks or blood products are considered low-risk (however, others such as surgeons and nurses require vaccination).
E. Infants are not routinely vaccinated for hepatitis B.
C. Infants are vaccinated for hepatitis B at birth. All healthcare and public safety workers exposed to blood on the job are vaccinated. Persons traveling to regions with high infection rates should consider vaccination. Others receiving vaccination include anyone with multiple sex partners, persons with liver disease and other hepatitis infections, illicit drug users, persons with liver disease or renal disease and anyone who wants protection.
The meningococcal disease can be prevented by the following vaccines: MCV4 and MPSV4. Select the vaccine formulation preferred for ages 2 months - 55 years (if available):
A. Menactra (MCV4)
B. Menveo (MCV4)
C. Menomune (MPSV4)
D. Merrem
E. Metadate
B. MCV4 is the preferred vaccine for people in these groups who are 2 months through 55 years of age. MPSV4 can be used for adults 56 and older. Menactra is for 9 months-55 years of age.
Menactra: ages 9 months to 55 years, MCV4 give IM
Menveo: ages 2 months to 55 years, MCV4 give IM
Menomune: ages > 56, MPSV4 give SC
Merram (meropenem)
Metadate (methylphenidate)