2.3 Exploding Cells And Acid Trouble

Question 1

Why do necrotic cells swell and burst?

Answer 1

Failure of action of Na,K,ATPase - sodium not being pumped out now so osmolality and oncotic pressure cause water to enter, swell, burst

Question 2

Oncotic pressure?

Answer 2

Form of osmotic pressure exerted by proteins
Higher oncotic pressure - water follows
E.g. Albumin in blood vessels

Question 3

Osmolarity and osmolality?

Answer 3

Osmolarity - conc of sol expressed as total no. Of solute particles per litre
Osmolality - conc of sol expressed as total no. Of solute per kg

Question 4

pH equation?

Answer 4

pH = -log[H+]

Question 5

One unit change in pH scale causes what fold change?

Answer 5

10 fold

Question 6

[H+] conc for pH 7.0 and 7.4 respectively? (Will help to work out [H+] at other pH)

Answer 6

100, 40

Question 7

What is shock?

Answer 7

Poor tissue perfusion, leads to cellular and tissue hypoxia, leads to lactic acid production, lowering pH - acidosis