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*Hematology Extern > 2.3 Coagulation System Disorders > Flashcards

2.3 Coagulation System Disorders Flashcards

1
Q

The APTT is sensitive to a deficiency of which clotting factor?
A. Factor VII
B. Factor X
C. PF3
D. Calcium

A

B. Factor X

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2
Q

Which test result would be normal in a patient with dysfibrinogenemia?
A. TT
B. APTT
C. PT
D. Immunologic fibrinogen level

A

D. Immunologic fibrinogen level

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3
Q

A patient with a prolonged PT is given intravenous vitamin K. PT is corrected to normal after 24 hours. Which clinical condition most likely caused these results?
A. Necrotic liver disease
B. Factor X deficiency
C. Fibrinogen deficiency
D. Obstructive jaundice

A

D. Obstructive jaundice

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4
Q

Which factor deficiency is associated with prolonged PT and APTT?
A. Factor X
B. Factor VIII
C. Factor IX
D. Factor XI

A

A. Factor X

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5
Q

Prolonged APTT is corrected with factor VIII–deficient plasma but not with factor IX– deficient plasma. Which factor is deficient?
A. Factor V
B. Factor VIII
C. Factor IX
D. Factor X

A

C. Factor IX

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6
Q

Which of the following is a characteristic of classic hemophilia A?
A. Abnormal PLT aggregation
B. Autosomal recessive inheritance
C. Mild to severe bleeding episodes
D. Prolonged PT

A

C. Mild to severe bleeding episodes

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7
Q

Refer to the following results:
PT = prolonged
APTT = prolonged
PLT count = decreased
Which disorder may be indicated?
A. Factor VIII deficiency
B. von Willebrand disease
C. DIC
D. Factor IX deficiency

A

C. DIC

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8
Q

Which of the following is a predisposing condition for the development of DIC?
A. Adenocarcinoma
B. Idiopathic thrombocytopenic purpura (ITP)
C. Post transfusion purpura (PTP)
D. Heparin-induced thrombocytopenia (HIT)

A

A. Adenocarcinoma

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9
Q

Factor XII deficiency is associated with:
A. Bleeding episodes
B. Epistaxis
C. Decreased risk of thrombosis
D. Increased risk of thrombosis

A

D. Increased risk of thrombosis

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10
Q

The following results were obtained on a patient: normal PLT count and function, normal PT, and prolonged APTT. Which of the following disorders is most consistent with these results?
A. Hemophilia A
B. Bernard–Soulier syndrome
C. von Willebrand disease
D. Glanzmann thrombasthenia

A

A. Hemophilia A

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11
Q

The following laboratory results were obtained from a 40-year-old woman: PT = 20 sec; APTT = 50 sec; TT = 18 sec. What is the most probable diagnosis?
A. Factor VII deficiency
B. Factor VIII deficiency
C. Factor X deficiency
D. Hypofibrinogenemia

A

D. Hypofibrinogenemia

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12
Q

When performing a factor VIII activity assay, a patient’s plasma is mixed with:
A. Normal patient plasma
B. Factor VIII–deficient plasma
C. Plasma with a high concentration of factor VIII
D. Normal control plasma

A

B. Factor VIII–deficient plasma

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13
Q

Which of the following is associated with an abnormal PLT aggregation test result?
A. Factor VIII deficiency
B. Factor VIII inhibitor
C. Lupus anticoagulant
D. Afibrinogenemia

A

D. Afibrinogenemia

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13
Q

The most suitable product for treatment of factor VIII deficiency is:
A. Fresh frozen plasma (FFP)
B. Factor VIII concentrate
C. Prothrombin complex concentrate
D. Factor V Leiden

A

B. Factor VIII concentrate

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14
Q

Refer to the following results:
PT = normal
APTT = prolonged
PLT count = normal
PLT aggregation to ristocetin = abnormal
Which of the following disorders may be indicated?
A. Factor VIII deficiency
B. DIC
C. von Willebrand disease
D. Factor IX deficiency

A

C. von Willebrand disease

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15
Q

Which results are associated with hemophilia A?
A. Prolonged APTT, normal PT
B. Prolonged PT and APTT
C. Prolonged PT, normal APTT
D. Normal PT and APTT

A

A. Prolonged APTT, normal PT

16
Q

Fibrin monomers are increased in which of the following conditions?
A. Primary fibrinolysis
B. DIC
C. Factor VIII deficiency
D. Fibrinogen deficiency

A

B. DIC

17
Q

Which of the following is associated with multiple factor deficiencies?
A. An inherited disorder of coagulation
B. Severe liver disease
C. Dysfibrinogenemia
D. Lupus anticoagulant

A

B. Severe liver disease

18
Q

Normal PT and APTT results in a patient with poor wound healing may be associated with:
A. Factor VII deficiency
B. Factor VIII deficiency
C. Factor XII deficiency
D. Factor XIII deficiency

A

D. Factor XIII deficiency

19
Q

Fletcher factor (prekallikrein) deficiency may be associated with:
A. Bleeding
B. Thrombosis
C. Thrombocytopenia
D. Thrombocytosis

A

B. Thrombosis

20
Q

One of the complications associated with a severe hemophilia A is:
A. Hemarthrosis
B. Mucous membrane bleeding
C. Mild bleeding during surgery
D. Immune-mediated thrombocytopenia

A

A. Hemarthrosis

21
Q

The most common subtype of classic von Willebrand disease is:
A. Type 1
B. Type 2A
C. Type 2B
D. Type 3

A

A. Type 1

22
Q

Prolonged APTT and PT are corrected when mixed with normal plasma. Which factor is most likely deficient?
A. Factor VIII
B. Factor V
C. Factor XI
D. Factor IX

A

B. Factor V

*Hematology Extern (18 decks)

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