1.5 Qualitative and Quantitative White Blood Cell Disorders

Question 1

Which of the following is an unusual complication that may occur in infectious mononucleosis?
A. Splenic infarctions
B. Dactylitis
C. Hemolytic anemia
D. Giant PLTs

Answer 1

C. Hemolytic anemia

Question 2

In a patient with HIV infection, one should expect to see:
A. Shift to the left in WBCs
B. Target cells
C. Reactive lymphocytes
D. Pelgeroid cells

Answer 2

C. Reactive lymphocytes

Question 3

Which inclusions may be seen in leukocytes?
A. Döhle bodies
B. Basophilic stippling
C. Malarial parasites
D. Howell–Jolly bodies

Answer 3

A. Döhle bodies

Question 4

Which of the following is contained in the primary granules of the neutrophil?
A. Lactoferrin
B. Myeloperoxidase
C. Histamine
D. Alkaline phosphatase

Answer 4

B. Myeloperoxidase

Question 5

What is the typical reference range for relative lymphocyte percentage in the peripheral blood smear from a 1-year-old child?
A. 1%–6%
B. 27%–33%
C. 35%–58%
D. 50%–70%

Answer 5

D. 50%–70%

Question 6

Qualitative and quantitative neutrophil changes noted in response to infection include all of the following except:
A. Neutrophilia
B. Pelgeroid hyposegmentation
C. Toxic granulation
D. Vacuolization

Answer 6

B. Pelgeroid

Question 7

Neutropenia is present in patients with which absolute neutrophil count?
A. Less than 1.5 × 109/L
B. Less than 5.0 × 109/L
C. Less than 10.0 × 109/L
D. Less than 15.0 × 109/L

Answer 7

A. Less than 1.5 × 109/L

Question 8

The morphological characteristic(s) associated with Chédiak–Higashi syndrome is (are):
A. Pale blue cytoplasmic inclusions
B. Giant lysosomal granules
C. Small, dark-staining granules and condensed nuclei
D. Nuclear hyposegmentation

Answer 8

B. Giant lysosomal granules

Question 9

The familial condition of Pelger–Huët anomaly is important to recognize because this disorder must be differentiated from:
A. Infectious mononucleosis
B. May–Hegglin anomaly
C. A shift-to-the-left increase in immature granulocytes
D. G6PD deficiency

Answer 9

C. A shift-to-the-left increase in immature granulocytes

Question 10

SITUATION: A differential shows reactive lymphocytes, and the physician suspects that a viral infection is the cause. What is the expected laboratory finding in a patient with a cytomegalovirus (CMV) infection?
A. Heterophile antibody: positive
B. Epstein–Barr virus (EBV)–immunoglobulin M (IgM): positive
C. Direct antiglobulin test (DAT): positive
D. CMV–IgM: positive

Answer 10

D. CMV–IgM: positive

Question 11

Neutrophil phagocytosis and particle ingestion are associated with an increase in O2 utilization called respiratory burst. What are the two most important products of this biochemical reaction?
A. Hydrogen peroxide (H2O2) and superoxide anion (O2–)
B. Lactoferrin and NADPH oxidase
C. Cytochrome b and collagenase
D. Alkaline phosphatase and ascorbic acid

Answer 11

A. Hydrogen peroxide (H2O2) and superoxide anion (O2–)

Question 12

Which of the morphological findings are characteristic of reactive lymphocytes?
A. High nuclear:cytoplasmic (N:C) ratio
B. Prominent nucleoli
C. Basophilic cytoplasm
D. All of these options

Answer 12

D. All of these options