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*Hematology Extern > 1.2 Normocytic and Normochromic Anemias > Flashcards

1.2 Normocytic and Normochromic Anemias Flashcards

1
Q

Hypersplenism is characterized by:
A. Polycythemia
B. Pancytosis
C. Leukopenia
D. Myelodysplasia

A

C. Leukopenia

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2
Q

Which of the following organs is responsible for the “pitting process” in RBCs?
A. Liver
B. Spleen
C. Kidney
D. Lymph nodes

A

B. Spleen

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3
Q

Spherocytes differ from normal RBCs in all of the following except:
A. Decreased surface to volume
B. No central pallor
C. Decreased resistance to hypotonic saline
D. Increased deformability

A

D. Increased deformability

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4
Q

Which of the following is not associated with HS?
A. Increased osmotic fragility
B. MCHC greater than 36%
C. Intravascular hemolysis
D. Extravascular hemolysis

A

C. Intravascular hemolysis

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5
Q

Which of the following disorders has an increase in osmotic fragility?
A. Iron deficiency anemia (IDA)
B. Hereditary elliptocytosis (HE)
C. Hereditary stomatocytosis
D. Hereditary spherocytosis (HS)

A

D. Hereditary spherocytosis (HS)

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6
Q

The anemia seen in sickle cell disease is usually:
A. Microcytic, normochromic
B. Microcytic, hypochromic
C. Normocytic, normochromic
D. Normocytic, hypochromic

A

C. Normocytic, normochromic

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7
Q

Which is the major Hgb found in the RBCs of patients with the sickle cell trait?
A. Hgb S
B. Hgb F
C. Hgb A2
D. Hgb A

A

D. Hgb A

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8
Q

Select the amino acid substitution that is responsible for sickle cell anemia.
A. Lysine is substituted for glutamic acid at the sixth position of the α-chain
B. Valine is substituted for glutamic acid at the sixth position of the β-chain
C. Valine is substituted for glutamic acid at the sixth position of the α-chain
D. Glutamine is substituted for glutamic acid at the sixth position of the β-chain

A

B. Valine is substituted for glutamic acid at the sixth position of the β-chain

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9
Q

All of the following are usually found in Hgb C disease except:
A. Hgb C crystals
B. Target cells
C. Lysine substituted for glutamic acid at the sixth position of the β–chain
D. Fast mobility of Hgb C at pH 8.6

A

D. Fast mobility of Hgb C at pH 8.6

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10
Q

Which of the following Hgbs migrates to the same position as Hgb A2 at pH 8.6?
A. Hgb H
B. Hgb F
C. Hgb C
D. Hgb S

A

C. Hgb C

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11
Q

Which of the following electrophoretic results is consistent with a diagnosis of the sickle cell trait?
A. Hgb A: 40% Hgb S: 35% Hgb F: 5%
B. Hgb A: 60% Hgb S: 40% Hgb A2: 2%
C. Hgb A: 0% Hgb A2: 5% Hgb F: 95%
D. Hgb A: 80% Hgb S: 10% Hgb A2: 10%

A

B. Hgb A: 60% Hgb S: 40% Hgb A2: 2%

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12
Q

In which of the following conditions will autosplenectomy most likely occur?
A. Thalassemia major
B. Hgb C disease
C. Hgb SC disease
D. Sickle cell disease

A

D. Sickle cell disease

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13
Q

Which of the following is most true of paroxysmal nocturnal hemoglobinuria (PNH)?
A. It is a rare acquired stem cell disorder that results in hemolysis
B. It is inherited as a sex-linked trait
C. It is inherited as an autosomal dominant trait
D. It is inherited as an autosomal recessive trait

A

A. It is a rare acquired stem cell disorder that results in hemolysis

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14
Q

Hemolytic uremic syndrome (HUS) is characterized by all of the following except:
A. Hemorrhage
B. Thrombocytopenia
C. Hemoglobinuria
D. Reticulocytopenia

A

D. Reticulocytopenia

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15
Q

The autohemolysis test result is positive in all of the following conditions except:
A. Glucose-6-phosphate dehydrogenase (G6PD) deficiency
B. HS
C. Pyruvate kinase (PK) deficiency
D. PNH

A

D. PNH

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16
Q

Which antibody is associated with paroxysmal cold hemoglobinuria (PCH)?
A. Anti-I
B. Anti-i
C. Anti-M
D. Anti-P

17
Q

All of the following are associated with intravascular hemolysis except:
A. Methemoglobinemia
B. Hemoglobinuria
C. Hemoglobinemia
D. Decreased haptoglobin

A

A. Methemoglobinemia

18
Q

Autoimmune hemolytic anemia (AIHA) is best characterized by which of the following?
A. Increased levels of plasma C3
B. Spherocytic RBCs
C. Decreased osmotic fragility
D. Decreased unconjugated bilirubin

A

B. Spherocytic RBCs

19
Q

“Bite cells” are usually seen in patients with:
A. Rh null trait
B. Chronic granulomatous disease
C. G6PD deficiency
D. PK deficiency

A

C. G6PD deficiency

20
Q

The morphological classification of anemias is based on which of the following?
A. Myeloid:erythroid (M:E) ratio
B. Prussian blue stain
C. RBC indices
D. Reticulocyte count

A

C. RBC indices

21
Q

Which of the following is a common finding in aplastic anemia?
A. A monoclonal disorder
B. Tumor infiltration
C. Peripheral blood pancytopenia
D. Defective deoxyribonucleic acid (DNA) synthesis

A

C. Peripheral blood pancytopenia

22
Q

Congenital dyserythropoietic anemias (CDAs) are characterized by:
A. Bizarre multinucleated erythroblasts
B. Cytogenetic disorders
C. Megaloblastic erythropoiesis
D. An elevated M:E ratio

A

A. Bizarre multinucleated erythroblasts

23
Q

Microangiopathic hemolytic anemia is characterized by:
A. Target cells and Cabot rings
B. Toxic granulation and Döhle bodies
C. Pappenheimer bodies and basophilic stippling
D. Schistocytes and NRBCs

A

D. Schistocytes and NRBCs

24
Q

Which antibiotic(s) is (are) most often implicated in the development of aplastic anemia?
A. Sulfonamides
B. Penicillin
C. Tetracycline
D. Chloramphenicol

A

D. Chloramphenicol

25
Q

Sickle cell disorders are:
A. Hereditary, intracorpuscular RBC defects
B. Hereditary, extracorpuscular RBC defects
C. Acquired, intracorpuscular RBC defects
D. Acquired, extracorpuscular RBC defects

A

A. Hereditary, intracorpuscular RBC defects

26
Q

Which of the following conditions may produce spherocytes in a peripheral blood smear?
A. Pelger–Huët anomaly
B. Pernicious anemia
C. AIHA
D. Sideroblastic anemia

27
Q

A patient’s peripheral blood smear reveals numerous NRBCs, marked variation of RBC morphology, and pronounced polychromasia. In addition to decreased Hgb and decreased Hct values, what other CBC parameters may be anticipated?
A. Reduced PLTs
B. Increased MCHC
C. Increased MCV
D. Decreased RDW

A

C. Increased MCV

28
Q

What RBC inclusion may be seen in the peripheral blood smear from a patient postsplenectomy?
A. Toxic granulation
B. Howell–Jolly bodies
C. Malarial parasites
D. Siderotic granules

A

B. Howell–Jolly bodies

29
Q

Reticulocytosis usually indicates:
A. Response to inflammation
B. Neoplastic process
C. Aplastic anemia
D. RBC regeneration

A

D. RBC regeneration

30
Q

Hereditary pyropoikilocytosis (HP) is an RBC membrane defect characterized by:
A. Increased pencil-shaped cells
B. Increased oval macrocytes
C. Misshapen budding fragmented cells
D. Bite cells

A

C. Misshapen budding fragmented cells

*Hematology Extern (18 decks)

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