22 - Neuropathic Pain Flashcards

1
Q

non-pharms

A
  • physiotherapy, mindfulness, yoga, exercise, psychotherapy, ensure enough sleep
  • evidence is lacking for these but provide no harm
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2
Q

A trial of ____ months is reasonable

A

2-3 months

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3
Q

meds for acute phase for nerve root compression?

A

NSAIDs or acetaminophen may be effective

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4
Q

1st line for chronic peripheral neuropathic pain

A

TCAs, gabapentinoids, SNRIs

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5
Q

2nd line for chronic peripheral neuropathic pain

A

tramadol and topical lidocane

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6
Q

When should you do a follow-up after starting meds for neuropathic pain?

A

1-2 weeks (to assess tolerability and s/e)

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7
Q

3rd line for chronic peripheral neuropathic pain

A

opioids (morphine, hydromorphone, oxycodone, transdermal fentanyl patch)

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8
Q

____ is an opioid that is a poor choice for any pain

A

codeine

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9
Q

Products with codeine or tramadol not for kids < ___ years old

A

12

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10
Q

4th line for chronic peripheral neuropathic pain

A

cannabinoids, methaodne tapentadol, lamotrigine, topiramate and botox

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11
Q

Risk factors for reactivation of VZV?

A

> 50 yo and decreased immunologic competence

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12
Q

Oral antivirals are most effective if started within ___ hours of the onset of the rash or severe pain

A

72

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13
Q

Options for acute pain of PHN?

A

amitriptyline and/or gabapentin and if necessary, opioids or nerve blocks

corticosteroids may improve QOL but does not accelerate healing so use them sparingly - not indicated for elderly, immunosuppressed, patients with DM, HTN, or GI ulcer

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14
Q

Trigeminal neuralgia is confined to the ____

A

face

*almost always unilateral

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15
Q

Trigeminal neuralgia usually responds to what drug?

A

Carbamazepine - measuring levels is not necessary but may be helpful to assess adherence or concerns regarding toxicity

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16
Q

if CBZ doesn’t work for trigeminal neuralgia, what is the next option?

A

oxcarbazepine

17
Q

table 4 on page 347 has really good review

A

ok

18
Q

Options for neuropathic pain in pregnancy?

A
  • TCAs
  • SNRIs
  • topical lidocaine
  • clonazepam prob safe but other spots say to avoid BZD in pregnancy
  • opioids are safe but monitor baby once born
19
Q

Can you use CBZ or oxcarbazepine in pregnancy?

A
  • CBZ can cause neural tube defects

- they are unsure about oxcarbazepine

20
Q

If person is using CBZ or oscarbazepine in pregnancy, what must they supplement with?

A

folic acid

21
Q

Most of these drugs mentioned are ok for breastfeeding. Which ones are not recommended?

A
  • chronic BZD not recommended if breastfeeding
  • avoid pregabalin until we get more data
  • don’t recommend codeine
22
Q

Gabapentinoids need dose adjusment if CrCl < ___

A

60 mL/min

23
Q

Venlafaxine need dose adjusment if CrCl < ___

A

70 mL/min