22. DSA Coagulation

Question 1

If you get a cut in your skin, circulating platelets will come and deposit in the area. Is this enough?

Answer 1

NO! not enough so fibrin strands come to hold mesh together

Question 2

Fibrin (known as 1) is made up of subunits which have a natural affinity for eachother, forming a polymer. What circulates in the blood (different form of fibrin)

Answer 2

Fibrinogen (with something covering the active site so it does not react normally in the blood)

Question 3

How does the body know to convert fibrinogen to fibrin at the site of damage?

Answer 3

New proteins are being released at the site by endothelial cells

Question 4

What does the intrinsic pathway (workhorse) consist of?

Answer 4

12, 11, 9, 10, 8, 5, (activated 10)

Question 5

What does the extrinsic pathway (the spark) consist of?

Answer 5

TissueFactor 3 to 7 to 10 to 2 (thrombin)

Question 6

What does thrombin activate?

Answer 6

5,7,8,11,13

Question 7

What does factor 13 do?

Answer 7

crosslink fibrin strands

Question 8

Thrombin helps create plasmin from plasminogen which does what?

Answer 8

acts on mesh crosslinked fibrin and breaks them apart

Question 9

Thrombin also stimulates antithrombin which does?

Answer 9

Decreases amount of thrombin being produced from prothrombin, decreases activated 10

Question 10

Haemophilia A B and C cause deficiency in what?

Answer 10

8 9 and 11, intrinsic pathway deficiency