22. Dermis

Question 1

Dermis is from:
FNXS
Contains

Answer 1

mesoderm
structure and flexible, vascular and immuno, nerve
has adnexal strucutres

Question 2

Contents of ECM

Answer 2

Collagen = main
elastic fibers
extrafibular matrix
to regulate cell fusnton and provide support to dermis

Question 3

collagen produced from

provieds what?

Answer 3

dermal fibroblasts

very strong and minimal stretch

Question 4

Col I vs

Col III

Answer 4

Col I: most abundant in skin

Col III: embryo/babies and wound healing

Question 5

What collaged is in basement membrane

Answer 5

IV, VII, XVII

Question 6

Elastic fibers made of and provide

Answer 6

microfibrils and elastin and provide elasticity

Question 7

Whats in the Extrafibrillar matrix

Answer 7

water, electrolytes, plasma pro, proteoglycancs

Question 8

Where are fibroblasts derived from and what do they do

Answer 8

from mesoderm

make ECM: collagen, elastic fibs and ground substance

Question 9

HOw is collagen made

Answer 9

polypep on RER–> ER and GOLGi modifaction and glycosylation–> then intracellu is now procollagen–> extracell gets N and C cleaved and assembed

Question 10

Where are blood vessels in skin

Answer 10

btw dermins and subQ

Question 11

Where are free nerved endings in skin
Meisners corpuscles
Pancinian corpuscles

Answer 11

free is at epidermis
meissners is superficial skin for light touch, fingertips
Pancinian: deep in dermis for pressure and weight bearing

Question 12

autosomal dom fibrillin disease

Answer 12

Marfan

Question 13

Disorder of CT: usually collagen production with vairable presentation

Answer 13

Ehlers danlos

Question 14

Autoimmune disease causing sclerosis or thickening of skin, more women then men and show as violaceous plaques then turns to hard scaly plaques

Answer 14

Morphea–collagen forms in sheets not individually

Question 15

Complication of morphea

Answer 15

lim and joint and neuro invovlement

Question 16

See sclerosis of skin, Raynaurds, telengtasia and internal organ involvement: pulmonary fibrosis, renal crises and esophagus

Answer 16

Systemic Sclerosis (see lady with contracture mouth or the one puple plauques

Question 17

Wound healing

Answer 17

Hemostasis–> inflammation–> profliferation–> Maturation

Question 18

Happens in hemostatis?

Answer 18

reflex vascnx
coag via plats
fibrin plug

Question 19

Happesn in inflammation

Answer 19

hours-days
vasodialation and permeability
leukos recruited

Question 20

Happends during proliferation

Answer 20

4-12 days: angiogeneiss by endothelial cells, collagen, elastin and matrix secreated by fibroblasts and re=epi by keritnocyte migration

Question 21

Maturation staget

Answer 21

12 day-2 yrs
inflammation cleared and fibroblast apoptosis
Blood vessel mature
collagen mature

Question 22

SubQ fat from and fnx

Answer 22

mesoderm
energy stores
insulation
shock absorbs

Question 23

reactive panniculits from step. pharngitis, oral contraceptives IBD or malignancy, more common women

Answer 23

Erytherma Nordosum

tender red nodules on skin