22. Dermis Flashcards
Dermis is from:
FNXS
Contains
mesoderm
structure and flexible, vascular and immuno, nerve
has adnexal strucutres
Contents of ECM
Collagen = main
elastic fibers
extrafibular matrix
to regulate cell fusnton and provide support to dermis
collagen produced from
provieds what?
dermal fibroblasts
very strong and minimal stretch
Col I vs
Col III
Col I: most abundant in skin
Col III: embryo/babies and wound healing
What collaged is in basement membrane
IV, VII, XVII
Elastic fibers made of and provide
microfibrils and elastin and provide elasticity
Whats in the Extrafibrillar matrix
water, electrolytes, plasma pro, proteoglycancs
Where are fibroblasts derived from and what do they do
from mesoderm
make ECM: collagen, elastic fibs and ground substance
HOw is collagen made
polypep on RER–> ER and GOLGi modifaction and glycosylation–> then intracellu is now procollagen–> extracell gets N and C cleaved and assembed
Where are blood vessels in skin
btw dermins and subQ
Where are free nerved endings in skin
Meisners corpuscles
Pancinian corpuscles
free is at epidermis
meissners is superficial skin for light touch, fingertips
Pancinian: deep in dermis for pressure and weight bearing
autosomal dom fibrillin disease
Marfan
Disorder of CT: usually collagen production with vairable presentation
Ehlers danlos
Autoimmune disease causing sclerosis or thickening of skin, more women then men and show as violaceous plaques then turns to hard scaly plaques
Morphea–collagen forms in sheets not individually
Complication of morphea
lim and joint and neuro invovlement
See sclerosis of skin, Raynaurds, telengtasia and internal organ involvement: pulmonary fibrosis, renal crises and esophagus
Systemic Sclerosis (see lady with contracture mouth or the one puple plauques
Wound healing
Hemostasis–> inflammation–> profliferation–> Maturation
Happens in hemostatis?
reflex vascnx
coag via plats
fibrin plug
Happesn in inflammation
hours-days
vasodialation and permeability
leukos recruited
Happends during proliferation
4-12 days: angiogeneiss by endothelial cells, collagen, elastin and matrix secreated by fibroblasts and re=epi by keritnocyte migration
Maturation staget
12 day-2 yrs
inflammation cleared and fibroblast apoptosis
Blood vessel mature
collagen mature
SubQ fat from and fnx
mesoderm
energy stores
insulation
shock absorbs
reactive panniculits from step. pharngitis, oral contraceptives IBD or malignancy, more common women
Erytherma Nordosum
tender red nodules on skin
