21. Epidermis Flashcards
Epidermis derived from:
fnx:
ectoderm, barrier
deepest layer of epiderms, attaches to BM and has keratinocytis stem cells
Stratum Basal
What type of cells are in Basal layer
keratinocytes
layer with differentiating keratinocytes, in most parts of body makes up most epiderms, makes keratin
Spinosum
What junx hold the epiderms together
Tight jnx, adherenes jnx and DESMOSOMES
then hemidesmosomes from basal to BMX
What fibers link all the epidermis together?
keratin intermediate filaments
Assembly of Intermediate filaments
Keratin–cleave N and C–> Herodimer of type I and type II–> Tetramer–> protofil–> IF
What is in the Granular layer?
keratohyalin grans; key is fillagrin
Lamellar grans; key is ceramies and is fats
Composed of corneocytes (lack nucleus) and primary barrier of epidermis
Cornified layer
none on oral, genital and oral
thin on face
What is Keratinizaiton
process of keratinocyte migration and maturation
28 days total
Where do keratinocytes proliferate
basal layer–> then exit cell cycle go to spinosum
Aquired bullous disease d/t autoantibodies to desmoglein 1 and 3
Permphigus Vulgaris
where does blistering occur in Pemphigus vulgaris?
Intraepidermal blisters (autoAb to demogelin 1 and 3)
Clincally guy comes in with back and oral blisters, they are flacci and rupture easily with nikolky +
Pemphigus vulgaris (desmoglein 1 and 3)
TX for Pemphigus Vulgus
Prednisone, Azothiprine, Myco mofetil and Rituximab
